The home team bowlers came to the fore, striking at regular intervals to leave Kerala 117 runs behind with one wicket standing.
Left-arm medium-pacer T Natarajan and left-arm spinner Rahil Shah with three wickets each did most of the damage while R Sai Kishore took two wickets.
Earlier, debutant M Shahrukh Khan (92 not out) missed out on a well-deserved ton as the hosts collapsed from 249 for 6 to 268 all out.
For Kerala, P Rahul was the only one to make a significant contribution with 59.
Late resistance from Sijimon Joseph (28 batting) meant that Tamil Nadu would have to wait till tomorrow to wrap up the innings.
Thampi dismissed Rahil Shah (0) and T Natarajan (0) in the 98th over to end Tamil Nadu's innings.
In response, Kerala suffered an early blow when the consistent Jalaj Saxena was bowled by Natarajan for 4.
Kerala then kept losing wickets.
Brief scores: Tamil Nadu 268 in 98 overs (M Shahrukh Khan 92 not out (155b, 8x4, 1x6), B Indrajith 87, M Mohammed 29, Sandeep Warrier 5 for 52, Basil Thampi 4 for 62) vs Kerala 151 for 9 in 75 overs (P Rahul 59 (116b, 5x4, 1x6), Sijomon Joseph 28 batting, T Natarajan 3 for 42, Rahil Shah 3 for 32).
At Indore: Hyderabad 124 all out in 35.3 overs (Himalay Agarwal 69 not out, Avesh Khan 7 for 24) vs Madhya Pradesh 539 for 4 in 136 overs (Ajay Rohera 255 batting, Rajat Patidar 51, Yash Dubey 128 batting).
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)