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Widely used heart disease risk calculators may be failing to identify a large proportion of Indians at risk, with nearly 80 per cent of patients who eventually suffered a heart attack not being classified as 'high-risk' beforehand, according to new research. The research titled "Comparison of ASCVD Risk Prediction Models in STEMI: Insights from a South Asian Cohort" was conducted by a team of scientists from Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, ESIC Medical College, Faridabad, the Delhi Cancer Registry at AIIMS, among others. The study, conducted on 4,975 patients with first-time heart attacks, found significant differences in how five major global risk prediction models categorised individuals, raising concerns over their reliability for South Asian populations. Researchers compared widely used tools such as the Framingham Risk Score (FRS), ACC/AHA ASCVD 2013 model, WHO risk charts, JBS-3 calculator and the newer Predicting Risk of ...
Bristol Myers Squibb (BMS) on Wednesday announced the launch of Kopozgo (Mavacamten), an oral, selective cardiac myosin inhibitor, in India. Kopozgo is the first and only oral, selective cardiac myosin inhibitor approved in India for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM), BMS said in a statement. Mavacamten was approved by the Central Drugs Standard Control Organisation (CDSCO), with an import license issued on March 6, 2025. "Kopozgo is now available to patients in India. The approval of Kopozgo in India is based on positive efficacy and safety results from two Phase III clinical trials, EXPLORER-HCM and VALOR-HCM," the statement said. Sanjay Sharma, General Manager and Managing Director, BMS India, mentioned, "This breakthrough brings hope to individuals and families facing this condition, giving clinicians a novel therapy to address the unmet need in treatment. Bristol Myers Squibb is committed to advancing cardiovascular care fo