You are here: Home » Companies » News
Business Standard

AstraZeneca's Covid-19 vaccine shows less effect against S Africa variant

Company has started adapting vaccine against variant, shot may be ready by autumn this year

Topics
AstraZeneca | Coronavirus Vaccine

Yueqi Yang | Bloomberg 

AstraZeneca, pharma, coronavirus, vaccine
Sarah Gilbert, the Oxford professor leading work on the AstraZeneca shot, said “more data” will be published soo

AstraZeneca’s Covid-19 vaccine has shown limited efficacy against mild disease caused by the variant first identified in South Africa, according to early data in a small phase trial.

Efficacy against severe Covid-19 cases, hospitalisation and deaths hasn’t yet been determined, “given that subjects were predominantly young healthy adults,” a spokesperson for said in a statement.

None of the participants in the study died or was hospitalised, according to the Financial Times, which first reported on the findings. The study, with a relatively small sample size of more than 2,000 individuals, hasn’t yet been peer-reviewed and is due to be published on Monday, the newspaper said. Patients in the randomised, double-blind study had a median age of 31.

“We do believe our vaccine could protect against severe disease, as neutralising antibody activity is equivalent to that of other Covid-19 vaccines that have demonstrated activity against more severe disease, particularly when the dosing interval is optimised to 8-12 weeks,” the spokesperson said.

Initial data indicates other immune responses, such as T-cell responses, may remain intact in the South African variant, the spokesperson added.

chart


The variant first identified in South Africa is emerging as a key threat to the world’s prospects for ending the pandemic as countries roll out initial vaccine doses. Although vaccine makers said their shots appear to maintain effectiveness against the U.K. variants, pharma are racing to develop booster shots against new strains as the virus evolves.

Oxford University and have started adapting their vaccine against this variant, the spokesperson said. Should it be needed, they will advance it through clinical development so that it’s ready for autumn delivery.

Sarah Gilbert, the Oxford professor leading work on the AstraZeneca shot, said “more data” will be published soon. Speaking to the BBC’s Andrew Marr show, she said it’s possible current vaccines won’t reduce the number of cases of the South Africa variant, but will reduce deaths, hospitalisations and severe cases of the disease.

“That’s really important for health care systems. Even if we are having mild and asymptomatic infections, to prevent people from going into hospital with Covid would have a major effect,” Gilbert said.

UK Vaccines Minister Nadhim Zahawi said all the country’s vaccines do have “some effect” on the South African strain, as well as the British variant. “We deploy the vaccines we have, they offer that protection against serious illness, hospitalisation and death, which is what we need to do,” he said in an interview with the BBC Sunday. Earlier this week, Astra’s executive vice-president for biopharmaceutical research scaled back expectations for how the vaccine would work against the variant.

“We’re not going to be surprised to see reduced efficacy,” Mene Pangalos said. “It’s to be expected that there will be reduced activity.”


Dear Reader,


Business Standard has always strived hard to provide up-to-date information and commentary on developments that are of interest to you and have wider political and economic implications for the country and the world. Your encouragement and constant feedback on how to improve our offering have only made our resolve and commitment to these ideals stronger. Even during these difficult times arising out of Covid-19, we continue to remain committed to keeping you informed and updated with credible news, authoritative views and incisive commentary on topical issues of relevance.
We, however, have a request.

As we battle the economic impact of the pandemic, we need your support even more, so that we can continue to offer you more quality content. Our subscription model has seen an encouraging response from many of you, who have subscribed to our online content. More subscription to our online content can only help us achieve the goals of offering you even better and more relevant content. We believe in free, fair and credible journalism. Your support through more subscriptions can help us practise the journalism to which we are committed.

Support quality journalism and subscribe to Business Standard.

Digital Editor

First Published: Mon, February 08 2021. 00:08 IST
RECOMMENDED FOR YOU
.