"Those who have over the past 70 years created tension, launched wars and caused destruction in the region and have committed genocide and caused Sabra and Shatila (massacre) are in no position to portray Iran as a threat," said Rouhani.
"Iran is no threat to anyone. Iran is (the pillar) of stability and security for the entire region," Rouhani said.
Also, he maintained that the development of Iran's missile program is aimed at safeguarding peace and security in the region, and "it will strongly defend its rights."
On Tuesday, Netanyahu said that Iran was responsible for "darkness descending" on the Middle East.
Netanyahu also said that "Iran is building an aggressive empire."
"Despite Netanyahu's claims, the fact is that illegal occupation lies at the heart of most of the calamities in our region," Zarif tweeted on Tuesday.
"Historically, occupying another's land has never been sustainable. This occupation, too - and the apartheid system that perpetuates it - will not last long," Zarif said.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)