The 43-year-old actor, who is a vocal supporter of #MeToo, said she has noticed the shift in the film industry firsthand.
"Since Time's Up, I've been in meetings and on set and there's not a moment that there isn't a conversation happening. We've recognised that it's going to get ugly and now it's about who has the tenacity to see it through.
"We're in pre-production on a film right now and we've worked really hard to make everyone very aware that the industry needs to change," Theron told Elle magazine.
The "Mad Max: Fury Road" star emphasised on evolving with times and providing greater opportunities, irrespective of gender.
"We need to start hiring differently and we need to create opportunities for a gender-neutral set," she added.
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