"Iran believes Syria has the right to legitimate self- defence. To cover their crimes in the region, Israeli officials are resorting to lies against other countries," foreign ministry spokesman Bahram Ghasemi told AFP.
Israel struck targets inside Syria on Saturday after intercepting what it said was an Iranian drone entering its airspace from Syria, which it labelled an "attack."
An Israeli fighter jet crashed under fire from Syrian air defences.
That prompted Israel to unleash a dozen retaliatory strikes on both Syrian and Iranian targets inside Syria.
"The allegations regarding surveillance by an Iranian drone are too ridiculous for words," said Ghasemi.
The statement said the Israeli air strikes had targeted drones used in the fight against "terrorist organisations, primarily Daesh", referring to the Islamic State jihadist group.
"Iran does not have a military presence in Syria, and has only sent military advisers at the request of the Syrian government," Ghasemi told AFP.
"We deny all unfounded allegations by the Zionists. The government and Syrian army are only defending themselves against Israeli aggression."
Lebanon also criticised the Israeli strikes, and said it would write a letter of protest to the United Nations over the use of its airspace for the raids, according to a statement from its foreign ministry.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)