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South African variant could reduce vaccine protection: Pfizer-BioNTech

However, human trials are still to be conducted in this regard

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Coronavirus | Coronavirus Tests | Coronavirus Vaccine

IANS  |  New York 

WHO nod for Pfizer Covid vaccine may allow better access to poor nations
The pharmaceutical companies believe that the flexibility of BioNTech's proprietary mRNA vaccine platform is well suited to develop new vaccine variants, if required

The South African variant of Covid-19 may significantly reduce antibody protection from the Pfizer-BioNTech vaccine, as per a laboratory study, the pharmaceutical companies said. However, human trials are still to be conducted in this regard.

According to the study, published in The New England Journal of Medicine, although the results indicated a reduction in neutralisation of virus with all the South African variant spike glycoprotein mutations, the vaccine was still able to neutralise the virus.

This finding is consistent with recent reports of the neutralisation of variant SARS-CoV-2 or corresponding pseudoviruses by convalescent or post-immunisation sera, the companies said in a statement on Wednesday.

Pfizer and the University of Texas Medical Branch (UTMB) investigated the full set of South African variant (also known as B.1.351 lineage) spike mutations.

To this aim, three genetically engineered recombinant viruses were produced. One virus had the full set of spike glycoprotein mutations found in the South African variant and the other two had subsets of these mutations.

The viruses were tested against a panel of sera from 15 participants in the previously reported Phase 3 trial who had been immunised with the Pfizer-BioNTech Covid-19 vaccine.

Pfizer-BioNTech said they are taking the necessary steps, making the right investments, and engaging in the appropriate conversations with regulators to be in a position to develop and seek authorisation for an updated mRNA vaccine or booster once a strain that significantly reduces the protection from the vaccine is identified, the company said.

Pfizer-BioNTech are currently evaluating neutralisation of SARS-CoV-2 with the Brazilian strain spike mutations, as well as mutations from other emerging SARS-CoV-2 variants, and they continue to conduct studies to monitor the vaccine's real-world effectiveness.

The pharmaceutical companies believe that the flexibility of BioNTech's proprietary mRNA vaccine platform is well suited to develop new vaccine variants, if required.

(Only the headline and picture of this report may have been reworked by the Business Standard staff; the rest of the content is auto-generated from a syndicated feed.)

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First Published: Thu, February 18 2021. 18:52 IST
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