Wearing a dress designed by British designer Clare Waight Keller, Ms Markle was met by Prince Charles, who walked her down the aisle.
Harry, 33, and Meghan, 36, became the sixteenth Royal Couple to celebrate their Marriage at Windsor Castle since 1863. The newly-wed royal couple would be doing a tour of the city centre of Windsor in a traditional horse-driven Ascot Landau carriage.
Among the guests were Oprah Winfrey, George and Amal Clooney, David and Victoria Beckham, Serena Williams and Sir Elton John.Thousands of well-wishers are in Windsor, while hundreds more camped out overnight to secure the best viewing spot to witness the lavish royal wedding on Saturday.
Millions were also expected to watch on TV when Elizabeth's popular grandson and the American star of the TV drama "Suits" tie the knot at the 15th Century St George's Chapel in Windsor Castle, the oldest and largest inhabited castle in the world.
Before the wedding ceremony began, The Kensington Palace has released the official 'Order of Service' for Prince Harry and Meghan Markle's wedding ceremony.
Kensington Palace released the 'Order of Service' for Harry and Meghan's wedding and the most noticeable element of the document is that Thomas Markle, Meghan's father, is still included as the person who will walk Meghan down the aisle to the high altar of St. George's Chapel. (Although, it was updated by the palace that due to Meghan father's health issue, Prince Charles will walk her down the aisle.)
Meghan Markle. Photo: ReutersThe 'Order of Service' states that the American actress has omitted the word 'obey' from her vows following in the footsteps of Princess Diana and Kate Middleton. The amended vow reads, "I Meghan, take you, Harry, to be my husband, to have and to hold from this day forward; for better, for worse, for richer, for poorer, in sickness and in health, to love and to cherish, till death us do part; according to God's holy law. In the presence of God, I make this vow."
Prince Harry's vows are as follows: "I Harry, take you, Meghan, to be my wife, to have and to hold from this day forward; for better, for worse, for richer, for poorer, in sickness and in health, to love and to cherish, till death us do part; according to God's holy law. In the presence of God, I make this vow."
Photo: ReutersMoreover, the royal couple after marriage are now known as the Duke and Duchess of Sussex, making Markel the first woman entitled to use the title.
"The Queen has today been pleased to confer a Dukedom on Prince Henry of Wales. His titles will be Duke of Sussex, Earl of Dumbarton and Baron Kilkeel," the Kingston Palace said in a statement.
The programme revealed several details from the highly-anticipated festivities, including a schedule for the royal family's arrivals and the hymns to the vows.
The service concluded with a performance of 'Stand by Me' by Karen Gibson and The Kingdom Choir.
Approximately 600 guests, including Bollywood actress Priyanka Chopra, are expected to attend the royal wedding.
India's very own unofficial representative, Priyanka Chopra is reportedly at the royal wedding of Prince Harry and Meghan Markle, took to the authentic British plaid with a sass. She made her first public appearance after arriving to London donning a plaid suit from Alberta Ferretti.
On the social media platform, the 35-year-old Quantico actress, earlier was seen getting ready for the wedding.
More than 100,000 fans are expected to cram the narrow roads of Windsor, about 20 miles (30 km) west of London. Security was tight and visitors had to pass through police search points set up around the castle, home to 39 English monarchs since 1066.
The world's media has been gripped by the union of Harry, 33, the sixth-in-line to the British throne, and Markle, 36, a divorcee whose mother is African-American and father is white, and hundreds of TV crews descended on Windsor.
Before the wedding ceremonies took place, the bride arrived at the church with her mother, Doria Ragland, 61, with whom she was spent Friday night at a luxury hotel. Harry was staying at another hotel with elder brother and best man Prince William, whose daughter Charlotte and son George will be among the bridesmaids and page boys.
MARKLE'S MODERN OATH
Meghan Markle, background and her mother, Doria Ragland, arrive at Cliveden House Hotel, in Berkshire, England, Friday. Photo: PTI/APMarkle entered the chapel unescorted. Then Harry's father and heir-to-the-throne Prince Charles walked his future daughter-in-law down the aisle.
Her own father Thomas Markle, 73, a lighting director for TV soaps and sitcoms, pulled out this week, telling the US celebrity website TMZ he had undergone heart surgery on Wednesday.
Confusion over his attendance marred the build-up to the wedding, which had been carefully choreographed for months by royal aides and his name still appears in the order of service.
On Friday, Ragland met the 92-year-old monarch and her husband Prince Philip, 96, who will be among the senior royals in the 600-strong congregation.
The service will be conducted by the Dean of Windsor with Justin Welby, the Archbishop of Canterbury and the spiritual head of the Anglican Church, overseeing the exchange of vows.
A black US bishop, Most Reverend Michael Bruce Curry, gave the wedding address while Lady Jane Fellowes, the sister of Harry's late mother Princess Diana, will deliver the reading.
In a sign of modernity for the royals, Harry wore a ring while Markle will not vow to obey her husband. Senior male British royals do not traditionally wear rings.
Interspersed with traditional hymns, a choir will perform American soul singer Ben E. King's 196o's hit "Stand by me".
After the ceremony, the newlyweds are expected to greet some of the 1,200 members of the public specially invited into the grounds of the castle before setting off on a carriage procession through Windsor.
A reception will be held in the castle's St George's Hall before 200 guests join the couple at an evening event at Frogmore House, another grand mansion in the grounds.
The prince and his new wife, who are expected to be given a new title by the queen to mark their marriage, are not immediately leaving on honeymoon and will carry out their first official engagement as husband and wife next week.
Harry gained a reputation as a royal wild child who smoked cannabis, got drunk when underage, scuffled with paparazzi and drew outrage by dressing as a Nazi officer at a party.
But he turned his image around after joining the army, where he spent 10 years and included two tours of duty in Afghanistan.
Last year, he spoke openly of his emotional torment following the 1997 death of his mother in a Paris car crash.
Aged just 12, he walked solemnly behind her coffin in the funeral cortege.
His easy-going manner with the public is reminiscent of Diana, and he has picked up her campaigning baton with work on the welfare of military veterans, helping those with AIDS, and mental health issues.
WILD CHILD TURNED POPULAR PRINCE
(File photo) Britain's Prince Harry with his fiance Meghan Markle. Photo: PTIHarry met Markle on a blind date in July 2016 set up through a mutual friend. Harry said he had never heard of his future wife or watched her TV series, and she said she knew nothing of the prince.
But after just two dates, he whisked her off to Botswana for a holiday, camping under the stars.
"The fact that I fell in love with Meghan so incredibly quickly was confirmation to me that all the stars were aligned, everything was just perfect," Harry said when their engagement was announced last November.
Harry's gilded upbringing is in stark contrast with Markle's. She was born and raised in Los Angeles and her parents divorced when she was six.
After a number of minor roles in films and on TV, she won the role as Rachel Zane in "Suits". She ran a successful lifestyle blog, thetig.com, and has worked as a humanitarian campaigner. In 2011, she married film producer Trevor Engelson but they divorced in 2013.
The intense spotlight on her father this week was indicative of the limelight she now faces.
Harry, who has long had a testy relationship with the media, issued a public rebuke to journalists when they were dating, accusing some of sexism and racism. His mother's limousine was being chased by paparazzi just before her fatal crash.
Over the last 20 years since Diana's death, the royals have enjoyed much better media coverage with a sophisticated PR operation helping to turn round the perception of a hopelessly out-of-touch institution where the tribulations of the queen's children were played out in national newspapers.
Elizabeth famously described 1992 as an "annus horribilis" (horrible year) after three of her four childrenâ€™s marriages failed, including Charles' marriage to Diana, and part of Windsor Castle was badly damaged by fire.
The British remain broadly supportive of the monarchy albeit with a sense of mild irony about the pomp and pageantry that accompanies it, though many have deep respect for Elizabeth, after her 66 years of service.
Harry, along with brother William and his wife Kate, are at the forefront of an effort to modernise the monarchy by talking openly about their innermost feelings.
"It is just a maxim it is patently obvious the more you say, the more you can be examined," royal historian Hugo Vickers said. "Everything moves on gradually but there are certain risks and there is a lot to be said for maintaining the mystique."