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New drugs may help prevent hearing loss

IANS  |  New York 

Researchers have found that inhibiting a new enzyme protects mice and rats from noise or drug-induced

The study suggests that CDK2 inhibitors prevent the death of inner ear cells, which has the potential to save the hearing of millions of people around the world.

A team of researchers screened over 4,000 drugs for their ability to protect cochlear cells from the agent

is used to treat a variety of but causes irreversible in up to 70 per cent of patients, the said.

The researchers identified multiple compounds that protected cochlear cells from cisplatin, several of which are already approved to treat other conditions.

Three of the ten most effective compounds were inhibitors of an enzyme called CDK2.

One of these CDK2 inhibitors, kenpaullone, was more effective than four other compounds that are currently in clinical trials for treating hearing loss, the said.

Injecting kenpaullone into the middle ear protected both mice and rats from cisplatin-induced hearing loss, they added.

Moreover, kenpaullone also protected the hearing of mice to noise as loud as 100 dB.

"Given that 100-dB noise is in the range of noise insults commonly experienced by people in our society, kenpaullone could have significant clinical application in treating noise-induced hearing loss," said the lead author, from the St.

In the case of cisplatin-induced hearing loss, kenpaullone appears to protect hair cells by preventing CDK2 from stimulating the production of toxic reactive oxygen species from the cells' mitochondria, the said.

"The robust protection conferred by one-time local delivery of kenpaullone suggests that CDK2 inhibitors may transform the clinical prevention and treatment of - and noise-induced in patients," Zuo said in a paper published in the Journal of Experimental

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(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Sat, March 10 2018. 19:20 IST
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