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Stored blood may be unsafe for severely injured patients

IANS  |  New York 

stored for long may be less safe for patients with massive loss and as it may have adverse effects on them, researchers, including one of Indian origin, suggest.

The researchers found that for patients who have massive and receive many transfusion units, older was associated with in blood flow, increased and in critical end organs, and

The link between older stored and is free heme -- a from degraded red blood cells, the researchers said.

Heme is part of the oxygen-binding hemoglobin pigment that gives blood cells their red colour and carries oxygen through the body from the lungs.

Free heme is known to induce to major organs in like sickle cell or During storage and upon transfusion, stored red blood cells lyse open, releasing free heme.

"An adverse role for heme suggests that finding ways to limit heme exposure or prevent heme toxicity may improve safety of stored red blood cell transfusions," of the study Rakesh Patel, at the University of at Birmingham.

For the study, published in the journal PLOS Medicine, mice were resuscitated after trauma and hemorrhage, using either fresh or two-week-old stored blood.

Two days later, they were challenged by instilling the lungs with the aeruginosa. A two-week storage of mouse blood approximates storage of human red blood cells for 42 days.

Compared to fresh blood, with the stored blood significantly increased bacterial lung injury, as shown by higher mortality, and increases in fluid accumulation and bacterial numbers in the lungs.

Free heme acts, in part, by activating the toll-like receptor 4, the said.

The researchers also found that transfusion with stored blood induced release of the mediator HMGB1, part of the body's immune response.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Sat, March 10 2018. 17:16 IST