Netanyahu said he told Washington and Moscow today that Israel will act according to its "security needs."
Israel has largely stayed out of the war but has struck suspected weapon convoys to Hezbollah.
His remarks came on the heels of an international agreement laying out principles for post-war Syria.
A US-Russian statement Saturday affirmed an understanding calling for "the reduction and ultimate elimination" of foreign fighters.
Israel has long complained about the involvement of archenemy Iran, and its proxy Hezbollah, in Syria.
It has expressed concerns of a "Shiite corridor" with land links from Iran to Lebanon, providing movement of militants and weapons across the region.
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