"Resting Messi is a possibility like any other, but I think he is playing well, the other day he played a good game," Valverde said on Monday.
"We will make changes to the team in Vigo, I think it's an important week and that the team needs the rest."
Messi has only recently recovered from a knock to his knee while Sergio Busquets has been playing through the pain of a broken toe.
Ivan Rakitic suffered a broken finger last week and may also miss out.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)