Lurking deep inside some tumours are "factories" full of immune cells that help the body fight a rearguard action against cancer and are key to helping some patients recover, new research has shown.
In recent years, doctors have turned to a new treatment for cancer, immunotherapy, which works by leveraging the body's immune system to fight tumours.
The technique has largely focused on white blood cells called T-cells, which are "trained" to recognise and attack cancer cells.
But the innovative treatment only works well for around 20 per cent of patients, and researchers have been trying to understand why some people respond better than others.
Three papers published on Thursday in the journal Nature point the way, identifying a key formation inside some tumours: tertiary lymphoid structures (TLS).
These structures function like "factories or schools" for immune cells that help the body fight cancer, said Wolf H. Fridman, a professor emeritus of immunology at the Cordeliers Research ...

Scientists find powerhouses that fight tumours from within

PTI Automatic

Veteran country singer Reba McEntire is set to appear on the comedy series "Young Sheldon" in a guest role.
CBS has announced McEntire will feature in an upcoming episode of the show airing in February, reported Variety.
The 64-year-old singer will play June, "the fun, fiery ex-wife" of coach Ballard (essayed by Craig T Nelson), who strikes up an unlikely friendship with Meemaw (Annie Potts), who is currently dating Ballard.
"Young Sheldon", a spin-off of "The Big Bang Theory" by Chuck Lorre, stars Iain Armitage in the title role.
It also features with Zoe Perry, Lance Barber, Raegan Revord, Montana Jordan, and the voice of Jim Parsons, the adult Sheldon.
The series is currently in its third season and has been renewed through season four.

Reba McEntire to guest star in 'Young Sheldon'

The United States on Wednesday resumed joint military operations with Iraq that had been put on pause after the US drone strike that killed a top Iranian general in Baghdad, the New York Times reported.
Two US military officials quoted by the paper said the Pentagon wanted to resume these operations in order to pick up the fight against the Islamic State group.
Washington began the pause on January 5 two days after the strike that killed Iranian general Qasem Soleimani at the Baghdad airport.
The same day of the suspension furious Iraqi lawmakers voted to expel the more than 5,000 US troops that are in Iraq.
It was not immediately clear if anyone in the Iraqi government had approved the resumption of the joint military operations, the Times reported.
The Pentagon said it had no information to provide concerning a resumption when contacted by AFP.
Secretary of State Mike Pompeo said Monday that Iraqi leaders have told him privately they support the US troop presence, despite public ...

US resumes joint military operations in Iraq: NYT

"House of the Dragon", the prequel to epic fantasy series "Game of Thrones", is set to air in 2022, HBO president of programming Casey Bloys has said.
The spinoff of the popular HBO show has received a straight-to-series order.
"My guess is sometime in 2022," Bloys told Deadline about the premiere, adding it was too early to be more specific than that.
"They are starting writing," he said of the project from book series author George RR Martin and "Colony" scribe Ryan Condal.
The new spinoff will be based on "Fire & Blood", a companion book to Martin's "Song of Fire and Ice" saga, on which "GOT" is based.
The pilot of the new prequel is set 300 years before the events of the flagship series and tells the story of House Targaryen, rich in the dragonlord ancestors of Daenerys (played by Emilia Clarke).
Bloys revealed there is no casting new yet and getting "House of the Dragon" on air is his "number one priority".
"There are no other blinking green lights or anything like that. ...

'Game of Thrones' spinoff 'House of the Dragon' eyeing 2022 launch

Phil Mickelson says despite his fast-approaching 50th birthday he's determined to stay on the US PGA Tour while he can "bomb" golf balls and yearns for a Ryder Cup berth.
"When I stop hitting bombs I'll play the (50-and-over) Champions Tour," Mickelson said Wednesday.
"But I'm hitting some crazy bombs right now. No, I still have speed. There's no reason I couldn't play out here. I hit the ball every bit as far."
Mickelson, who turns 50 on June 16, spoke on the eve of the American Express tournament, where he serves as host.
The three-course event in the California desert will be contested at the PGA West Nicklaus and Stadium layouts and at LaQuinta Country Club.
The US left-hander won the 2013 British Open then went nearly five years without a victory before taking the 2018 WGC Mexico Championship and last year added his fifth Pebble Beach Pro-Am title for his 44th career US PGA crown.
But he failed to qualify for last month's Presidents Cup in Australia, the first US team event ...

Mickelson aims for Ryder Cup, more 'bombs' as 50 nears

Kylian Mbappe scored twice to take his season tally to 20 as the French World Cup winner shone in Paris Saint-Germain's 4-1 rout of his former club Monaco on Wednesday.
The victory kept PSG eight points clear at the top.
They also registered their 50th goal of the league campaign from 20 matches.  Monaco came away from PSG with a point in a thrilling 3-3 draw in the capital last weekend but they posed no similar threat just three days later.
Mbappe was on target in the 24th and 90th minutes with Neymar tucking away a penalty in first-half stoppage time.
Pablo Sarabia added another in the 73rd minute, just seconds after coming on as a substitute.
Ibrahima Bakayoko grabbed a late consolation for Monaco, beating the impressive Kaylor Navas in goal.
"In every area, we were better than Sunday," said PSG coach Thomas Tuchel.
"It's a deserved victory, we had lots of possession." Tuchel fielded his 'Fab Four' attacking stars in Mbappe, Neymar, Mauro Icardi and Angel Di Maria.
It was a ...

Mbappe returns to haunt Monaco, hits 20th goal of season

Asian markets rose early Thursday as details were released of the China-US trade deal signed in Washington, with analysts saying it would allow investors to turn their focus to the global outlook and earnings season.
After years of painstaking on-off talks between the economic superpowers, Donald Trump finally put pen to paper on an agreement that lowers tensions between the two and provides a major boost to the global outlook.
Equities have been rallying since last month's announcement of a deal to de-escalate a long-running stand-off that has jolted growth around the world and fanned fears of recession in some countries.
The pact -- the first part of a wider agreement -- includes pledges from Beijing to boost purchases of US agricultural goods and other exports for two years, protects US technology and provides enforcement mechanisms allowing Washington to impose penalties that Beijing cannot respond to.
In return, the US has cut tariffs on some Chinese products and cancelled others 

Asian markets rise as China, US finally put pen to paper on deal

Cristiano Ronaldo was too ill to play, while Zlatan Ibrahimovic spent the evening resting on the bench, but even without their biggest stars, Juventus and AC Milan cruised into the last eight of the Italian Cup on Wednesday.
Juventus beat visiting Udinese 4-0 in the late game, after Milan had dispatched SPAL, 3-0.
In the first game of the evening, 10-man Fiorentina beat Atalanta 2-1.
Ronaldo was sidelined after suffering an attack of sinusitis in the afternoon, but he is not the only ace in the Juventus pack.
After 16 minutes, Paulo Dybala carved through Udinese with a series of quick one-twos, finishing with a couple of exchanges with centre forward Gonzalo Higuain.
When his Argentine compatriot played a pass one little behind him, Dybala spun and floated the ball onto Higuain's chest and he strode forward and scored.
"That was a goal of rare beauty, to see three or four exchanges like that at high speed. It was worth the price of the ticket," said Juve coach Maurizio Sarri.
"I love .

Juventus score 'goal of rare beauty' in Italian Cup cruise

Ireland rode a career-best 95 from opener Paul Stirling before keeping their nerve in a nail-biting final over to pull off a four-run win over world champions West Indies in the first of a three-match Twenty20 series on Wednesday.
The burly Stirling steered Ireland to 208-7 in their 20 overs.
However, the home side appeared comfortably on course for victory -- bringing up their hundred inside 10 overs with just two wickets down -- until the game was decided in the last over.
Needing 15 to win, all-rounder Josh Little (3-29) got rid of the dangerous Dwayne Bravo, one of two wickets to fall in the last over.
With five needed off the last ball and seven wickets down, Hayden Walsh could only wave his bat into thin air in a desperate attempt to win the game.
It was only Ireland's second victory in T20 cricket over the West Indies who went into the game having swept the ODI series 3-0.
"Everyone is ecstatic, we came so close in that second ODI (lost by one wicket) and it maybe affected us ..

Ireland stun world champions Windies by four runs in T20 opener

Rain fell across parts of bushfire-ravaged eastern Australia on Thursday and more wet weather was forecast, giving some relief following months of catastrophic blazes fuelled by climate change.
The fires, unprecedented for Australia in terms of duration and intensity, have claimed 28 lives and killed an estimated billion animals.
Sustained hot weather and only very rare periods of light rain in the affected areas have deepened the crisis.
So authorities had been looking forward to this week's rain hoping it would help contain or even extinguish some fires.
In the state of New South Wales, where many of the worst fires have burnt, there were "good falls" on some blazes early Thursday, the local meteorology bureau reported.
In the southern city of Melbourne, thunderstorms late on Wednesday helped to clear bushfire smoke that had choked the city since the start of the week and disrupted the build-up to next week's Australian Open tennis tournament.
"Storms have improved air quality in ...

Relief as rain falls over Autralian bushfires

Rain fell across parts of bushfire-ravaged eastern Australia on Thursday and more wet weather was forecast, giving some relief following months of catastrophic blazes fuelled by climate change.
The fires, unprecedented for Australia in terms of duration and intensity, have claimed 28 lives and killed an estimated billion animals.
Sustained hot weather and only very rare periods of light rain in the affected areas have deepened the crisis.
So authorities had been looking forward to this week's rain hoping it would help contain or even extinguish some fires.
In the state of New South Wales, where many of the worst fires have burnt, there were "good falls" on some blazes early Thursday, the local meteorology bureau reported.
"Relief is here for a number of firefighters working across NSW," the state's Rural Fire Service said in a social media post accompanying video footage of rain falling in a burning forest.
"Although this rain won't extinguish all fires, it will certainly go a long ...

Relief as rain falls over Australian bushfires

Russian lawmakers will begin reviewing President Vladimir Putin's nomination of a little-known tax chief as the new prime minister on Thursday after his announcement of a sweeping constitutional shake-up fuelled speculation about his future plans.
The overwhelmingly Kremlin-loyal State Duma lower parliament is likely to approve Mikhail Mishustin for the role, following the shock resignation of the government in the wake of Putin's call for reforms to reshape Russia's political system.
The series of bombshell announcements made during and after Putin's state of the nation speech triggered speculation about his role past 2024, when his current presidential term expires.
Some suggested 67-year-old Putin, who is currently two years into his fourth presidential term and has steered the country since 1999, could be laying the groundwork to assume a new post or remain in a powerful behind-the-scenes role.
It is also unclear whether Mishustin, a relatively obscure technocrat disengaged from ..

Russian Parliament to review Putin PM pick after shock overhaul

Indian tennis ace Sania Mirza continued her winning run as she entered the women's doubles semifinals of the Hobart International here on Thursday.
Partnering Nadiia Kichenok of Ukraine, Sania defeated the American duo of Vania King and Christina McHale 6-2 4-6 10-4 in the quarterfinals.
In a match that was tied at 1-1, the fifth seed Indo-Ukranian duo of Sania and Kichenok put up dominating performance to prevail in the tie-break.
They will now lock horns against the Slovenian-Czech pair of Tamara Zidansek and Marie Bouzkova.
The 33-year-old Sania, who last played at China Open in October 2017, battled injury breakdowns before taking a formal break to give birth to her son Izhaan.

Sania enters women's doubles semifinals of Hobart International

Actor-singer Jennifer Lopez has revealed she was offered director Adrian Lyne's "Unfaithful" but she passed on the project as the script "wasn't all the way there" for her.
Actor Diane Lane later went on to star in the 2002 thriller, besides earning best actress nominations for a Golden Globe and an Academy Award.
"There was a movie called 'Unfaithful'. And it was offered to me and the script, for me, wasn't all the way there.
"I should have known that Adrian Lyne was going to kill it, but I didn't. Diane Lane was so perfect for it, and it was obviously meant to be her, but when I think about that... I want to literally, like, shoot my toe off. I do," Lopez told Vanity Fair magazine.
Despite mixed reviews, "Unfaithful" was a box office hit and Lane received critical acclaim for her performance.
The film also starred Richard Gere and Olivier Martinez.

Jennifer Lopez regrets turning down 'Unfaithful'

Filmmaker Quentin Tarantino says among the young actors in Hollywood today, he has hedged his bets on actor Chris Pine.
The Oscar-nominated director said Pine became a "movie star" for him after he starred in the film "Unstoppable".
Directed by Tony Scott, the 2010 thriller about a runaway freight train, also stars Denzel Washington.
"I think one of the things that's exciting about the movie is I am a huge Chris Pine fan. Now, to me, of the actors of his age, he's hands down my favourite  - of that group, of that era, of those guys.
"I think a case can be made that Pine hasn't taken the next big leap from 'Unstoppable'. Frankly, to tell you the truth, he's been good in other movies (but) he hasn't had that," Tarantino said in an appearance on The Ringer's podcast "The Rewatchables".
When host Bill Simmons joked Pine is "waiting" for Tarantino to write him a part, the director said though he has never collaborated with Pine, he would like to work with him.
"I'm the biggest fan of him ..

I am a huge Chris Pine fan: Quentin Tarantino

Grammy-winning singer Akon has announced that the paperwork has been signed to launch Akon City, a city named after him, in Senegal.
The Senegalese-American musician earlier discussed his plans for Akon City and he took to Twitter on Tuesday to make things official.
"Just finalized the agreement for AKON CITY in Senegal. Looking forward to hosting you there in the future," Akon, 46, captioned the photo in which he posed with Senegalese officials on Monday.
According to Billboard, Akon City will apparently be the country's first Leadership in Energy and Environmental Design (LEED) city, which will be a short drive from an international airport and will use its own cryptocurrency, Akoin, also named after the singer.
The city will be built on 2,000 acres of land gifted to Akon from the President of Senegal. The singer was born in St Louis, Missouri but is of Senegalese descent, and he spent significant parts of his childhood in the country.
The city will feature colleges, schools, an ...

Akon says he 'finalized the agreement' for his own city in Senegal

Fantasy historical drama "Britannia" has secured a third season run at Sky, the network has announced.
The new chapter of the lavishly-mounted series which follows the Roman conquest of Britain, penned by playwright Jez Butterworth, starts shooting later this year, reported Deadline.
Created by Jez Butterworth, Tom Butterworth and James Richardson, "Britannia" stars David Morrissey, Mackenzie Crook, Annabel Scholey and Eleanor Worthington-Cox.
The debut series was the first co-production between Sky and Amazon Prime Video.
Amazon said it is no longer involved in the show and will not air seasons two or seasons three.
Sky sources said the network was in "active conversations with a number of US partners" about finding a new home for the drama in America.
The first season of "Britannia", which included nine episodes, ran from January to March 2018, while the 10-part second season launched last November.

'Britannia' renewed for season three

Actor Tilda Swinton, best known for films such as "Orlando", "The Chronicles of Narnia" series, "Okja" and "Suspiria", will receive the British Film Institute's highest honour, the BFI Fellowship this year.
According to BFI's official website, the actor will receive the fellowship at the BFI Chair's annual dinner, on March 2 in London.
The award honours the Swinton's daring as a performer and her great contributions to film culture, independent film exhibition and philanthropy.
The 59-year-old actor said she is "happy and touched" by the honour.
"Fellowship and BFI are two of my favourite words. And the beginning and end of the reason I live my life in the cinema in the first place... And I share it entirely with my beloved filmmaking playmates, living and departed," Swinton said in a statement.
BFI chair Josh Berger said he is delighted that the actor has accepted the fellowship.
"It is a career full of courageous artistic choices that has earned her the deep respect of her peers, ...

Tilda Swinton to receive BFI fellowship

Actor-comic Awkwafina's semi-autobiographical comedy "Awkwafina is Nora From Queens" has received a second season order ahead of its series debut.
The series is slated to debut on Comedy Central on January 22.
"Awkwafina is Nora..." is inspired by the the actor's real-life growing up in New York's Queens, follows her character, Nora Lin, who lives with her father (BD Wong) and grandmother (Lori Tan Chinn). Bowen Yang also stars as her cousin.
Sarah Babineau and Jonas Larsen, co-heads of original content, Comedy Central made the announcement on Tuesday, reported Variety.
"We are in awe of Awkwafina's creative genius on every level and we could not be more excited to embark on a season two with the entire Lin family in 'Awkwafina is Nora From Queens'," Babineau and Larsen said.
The development came weeks after Awkwafina won the Golden Globe in musical or comedy film actress for her role in the Lulu Wang-directed "The Farewell".
"Awkwafina is Nora..." is executive produced by Awkwafina, .

'Awkwafina is Nora from Queens' renewed ahead of series premiere

Japanese car giant Toyota said Thursday it is investing nearly $400 million in a company working on commercialising electric flying cars for "fast, quiet and affordable air transportation services".
The investment in Joby Aviation comes as the automaker looks to expand into new sectors as the industry rapidly transforms, with president Akio Toyoda pledging to move the firm "from a car manufacturer to a mobility company".
"Air transportation has been a long-term goal for Toyota, and while we continue our work in the automobile business, this agreement sets our sights to the sky," Toyoda said in a statement announcing the investment.
"Through this new and exciting endeavour, we hope to deliver freedom of movement and enjoyment to customers everywhere, on land, and now, in the sky."
Founded in 2009, Joby Aviation is developing a four-passenger electric aircraft that takes off and lands vertically, like a helicopter, though it has multiple rotors.
The firm envisions the aircraft as a mode 

Toyota investing $400 million in flying car company

"John Wick" actor Lance Reddick has joined the cast of Oscar-winning actor Regina King's directorial debut "One Night in Miami".
The project is a big screen adaptation of Kemp Powers' 2013 stage play which finds iconic historical figures -- young boxer Cassius Clay, activist Malcolm X, singer Sam Cooke and football star Jim Brown hanging out together at a Miami motel.
Powers has also written the screenplay.
Kingsley Ben-Adir stars as Malcolm X, Eli Goree as Cassius Clay, Aldis Hodge as Jim Brown, and Leslie Odom Jr as Sam Cooke.
Reddick will essay the role of Brother Kareem, who was Malcolm X's bodyguard and confidante.
The story, which takes place on the evening of February 25, 1964, revolves around the four men who end up baring their true selves.
"One Night..." will features the music of Cooke, including the hit, "A Change Is Gonna Come".

Page 1089 -