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New gene linked to ovarian cancer discovered

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Scientists have identified a gene in mice that, if faulty, may increase the chance of developing ovarian cancer.

The gene, known as Helq, helps repair any damage to that happens when it is copied as cells multiply. So if the gene is missing or faulty, DNA errors could mount up, increasing the chance of developing.

The team, from Cancer Research UK's Research Institute, found that mice without either of the two copies of the Helq gene were twice as likely to develop ovarian tumours, as well as becoming less fertile.

Even losing just a single copy of the Helq gene was enough to cause a mouse to develop more tumours, researchers said.

"Our findings show that if there are problems with the Helq gene in mice it increases the chance of them developing ovarian and other tumours," said Dr Simon Boulton, senior author from Cancer Research UK's London Research Institute.

"This is an exciting finding because this might also be true for women with errors in Helq, and the next step will be to see if this is the case.

"If it plays a similar role in humans, this may open up the possibility that, in the future, women could be screened for errors in the Helq gene that might increase their risk of ovarian cancer," Boulton said.

"This study pulls together clues from a series of experiments building a picture of cell faults that could lead to ovarian cancer in women," said Dr Julie Sharp, Cancer Research UK's senior science information manager.

"Ovarian cancer can be hard to diagnose early and treat successfully so the more we know about the causes of the disease, the better equipped we will be to detect and treat it," Sharp said.

The research is published in the journal Nature.

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