You are here: Home » Current Affairs » Coronavirus » News
Business Standard

Govt may not allow mixing of Covid-19 vaccines for booster shots

On May 4, Biological E submitted an application seeking emergency use authorisation for its Covid vaccine Corbevax as a booster dose in adults fully vaccinated with Covishield or Covaxin

Coronavirus Vaccine | Vaccine | India vaccination

Press Trust of India  |  New Delhi 

As of now, mixing of Covid-19 vaccines is not allowed in the country which means the precaution dose is of the same vaccine as the first and second doses.

The government may not allow precaution dose of a COVID-19 other than the one used for primary in light of a CMC Vellore study which showed lack of uniformity in results upon mixing of jabs for booster shots, sources said on Thursday.

The Covid Working Group of NTAGI which reviewed the findings of the Christian Medical College (CMC) Vellore study last week stated that scientific evidence showed that administering a booster dose of Covishield after primary with Covaxin gives 6 to 10 times higher antibody level as compared to when Covaxin is given as the precaution dose after a gap of six months after the primary schedule.

"However, the same advantage was not observed when Covaxin as a booster shot was given after two Covishield doses," an official source told PTI.

"Considering programmatic challenges the matter would now be discussed in the NTAGI Standing Technical Sub-Committee meeting for final recommendation," the source said.

As of now, mixing of COVID-19 vaccines is not allowed in the country which means the precaution dose is of the same as the first and second doses.

Meanwhile on May 4, Biological E submitted an application to India's drug regulator seeking emergency use authorisation for its Covid Corbevax as a booster dose in adults fully vaccinated with Covishield or Covaxin.

According to the EUA application submitted to DCGI, Biological E in a phase-3 placebo-controlled clinical study, based on the drug regulator's nod, has evaluated the safety and immunogenicity of Corbevax as a single-dose booster in Covid-negative adults fully vaccinated with either Covishield or Covaxin.

The study was conducted on 416 subjects aged 18 to 80 who were vaccinated with two doses of either Covaxin or Covishield with the last jab administered at least six months prior to giving the booster dose of Corbevax. "The results showed a significant boost in immunogenicity in terms of neutralizing antibodies after 28 days when compared with placebo cohort in both Covishield and Covaxin arms.

"The safety profile of Corbevax was found similar to that of the earlier clinical trials," an official source had told PTI quoting the Hyderabad-based firm as having mentioned in the EUA application.

(Only the headline and picture of this report may have been reworked by the Business Standard staff; the rest of the content is auto-generated from a syndicated feed.)

Dear Reader,

Business Standard has always strived hard to provide up-to-date information and commentary on developments that are of interest to you and have wider political and economic implications for the country and the world. Your encouragement and constant feedback on how to improve our offering have only made our resolve and commitment to these ideals stronger. Even during these difficult times arising out of Covid-19, we continue to remain committed to keeping you informed and updated with credible news, authoritative views and incisive commentary on topical issues of relevance.
We, however, have a request.

As we battle the economic impact of the pandemic, we need your support even more, so that we can continue to offer you more quality content. Our subscription model has seen an encouraging response from many of you, who have subscribed to our online content. More subscription to our online content can only help us achieve the goals of offering you even better and more relevant content. We believe in free, fair and credible journalism. Your support through more subscriptions can help us practise the journalism to which we are committed.

Support quality journalism and subscribe to Business Standard.

Digital Editor

First Published: Thu, May 12 2022. 21:30 IST