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Study finds how stress may be making you sick

ANI  |  Washington D.C. [USA] 

is often a hidden that can literally make you sick.

A is providing new insight into how certain types of interact with immune cells and can regulate how these cells respond to allergens, ultimately causing physical symptoms and

The federally funded study showed how a receptor, known as corticotropin-releasing factor, or CRF1, can send signals to certain immune cells, called mast cells, and control how they defend the body.

"Mast cells become highly activated in response to stressful situations the body may be experiencing," said Adam Moeser, an who specializes in

"When this happens, CRF1 tells these cells to release that can lead to such as irritable bowel syndrome, asthma, and such as "

One chemical substance, histamine, is known to help the body get rid of invading allergens such as pollen, dust mites or the protein of a like a peanut or shellfish. The histamine causes an and in a normal response, helps the body clear the allergen from its system.

If a patient has a or is under a lot of stress, then this same response can be amplified, resulting in more severe symptoms ranging from trouble breathing, or possibly even death.

During the study, Moeser compared the histamine responses of mice to two types of stress conditions - psychological and allergic - where the immune system becomes overworked. One group of mice was considered "normal" with CRF1 receptors on their mast cells and the other group had cells that lacked CRF1.

"While the 'normal' mice exposed to stress exhibited high histamine levels and disease, the mice without CRF1 had low histamine levels, less and were protected against both types of stress," Moeser said. "This tells us that CRF1 is critically involved in some initiated by these stressors."

The CRF1-deficient mice exposed to allergic stress had a 54 percent reduction in disease, while those mice who experienced had a 63 percent decrease.

The results could change the way such as and the debilitating gastrointestinal symptoms of are treated.

The findings have been published in the Journal of Leukocyte Biology.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Thu, January 11 2018. 10:55 IST