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Study finds stroke drug could prevent Alzheimer's disease

ANI  |  Washington D.C. [USA] 

Researchers have found that a drug which could treat may also prevent

The University of findings have been published in the Journal of Experimental

The study shows that the genetically engineered protein 3K3A-protects the brains of mice with Alzheimer's-like symptoms, reducing the buildup of toxic peptides and preventing

3K3A-is a genetically modified version of a human blood protein called activated protein C, which reduces and protects both neurons and the cells that line the walls of blood vessels from death and degeneration. 3K3A-has beneficial effects in various mouse models of disease, including and It is currently being developed to treat in humans, where it has been shown to be safe, well tolerated, and capable of reducing intracerebral bleeding.

"Because of its neuroprotective, vasculoprotective, and anti-inflammatory activities in multiple models of neurological disorders, we investigated whether 3K3A-APC can also protect the brain from the toxic effects of amyloid-ß toxin in a mouse model of disease," said

Toxic amyloid-ß peptides accumulate in the brains of patients, leading to neurodegeneration and reduced blood flow within the brain. Zlokovic and colleagues found that 3K3A-APC significantly reduced the accumulation of amyloid-ß in the brains of mice that usually produce large amounts of the toxic peptide. 3K3A-APC treatment prevented these mice from losing their memory and helped maintain normal cerebral blood flow. The drug also suppressed within the brain, another common feature of

Zlokovic and colleagues found that 3K3A-APC protects the brain by preventing nerve cells from producing an enzyme called BACE1 that is required to produce amyloid-ß. Several different inhibitors of BACE1 have been tested in clinical trials for Alzheimer's disease, but the new study suggests that using 3K3A-APC to block the production of BACE1 could be an alternative approach, particularly at early stages of the when amyloid-ß has yet to accumulate to levels capable of permanently damaging the brain.

"Our present data support the idea that 3K3A-APC holds potential as an effective anti-amyloid-ß therapy for early stage in humans," Zlokovic said.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Wed, January 16 2019. 17:09 IST