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Diet may help halt breast cancer spread: Study

IANS  |  New York 

Limiting the intake of foods rich in including dairy, beef, poultry, eggs, fish, nuts, soy and whole grains, while increasing the intake of fruits and vegetables may potentially help halt the spread of a deadly type of breast cancer, researchers, including one of Indian-origin, suggests.

is an amino acid -- the building blocks that cells use to make proteins.

The findings showed that limiting amino acid in laboratory mice with triple-negative breast dramatically reduced the ability of the to travel to distant sites in the body.

"Our study adds to a growing body of evidence that suggests diet can influence the course of the disease," said lead authpr Simon Knott, Associate at the -- a US-based non-profit.

"This study may have implications not only for breast cancer, but for many metastatic cancers," added Ravi Thadhani, from the varsity.

In the study, published in the journal Nature, the team discovered that the appearance of asparagine synthetase -- the enzyme cells used to make asparagine -- in a primary was strongly associated with later spread.

Further, was found greatly limited by reducing asparagine synthetase, treatment with the drug L-asparaginase, or dietary restriction.

When the lab mice were given rich in asparagine, the cancer cells spread more rapidly.

"The study suggests that changes in diet might impact both how an individual responds to primary therapy and their chances of spreading later in life," said Gregory J. Hannon, at the in England.

Researchers are now considering conducting an early-phase clinical trial in which healthy participants would consume a low-asparagine diet.

If the findings are confirmed in human cells, limiting the amount of patients ingest could be a potential strategy to augment existing therapies and to prevent the spread of breast cancer, Knott added.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Thu, February 08 2018. 12:52 IST