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Novel system to predict outcome of chemotherapy

IANS  |  New York 

Scientists have developed a new that uses red- and near-light to predict response to by as early as two weeks.

"There is currently no method that can predict treatment outcome of early on in treatment, so this is a major advance," said Andreas Hielscher, at

The novel dynamic "optical tomographic breast imaging system" generates three-dimensional (3-D) images of both breasts simultaneously.

The images also enable the researchers to look at blood flow in the breasts, see how the vasculature changes, and how the blood interacts with a

"This helps us distinguish malignant from healthy tissue and tells us how the is responding to earlier than other imaging techniques can," Hielscher said, in a paper published in the journal Radiology.

Neoadjuvant chemotherapy is the standard treatment for some women with newly diagnosed But fewer than half of women treated with the chemotherapy achieve a complete response.

"If we know early that a patient is not going to respond to the treatment they are getting, it may be possible to change treatment and avoid side-effects," said Dawn Hershman, also a at the varsity.

The researchers analysed imaging data from patients with and captured a series of images during a breath hold of at least 15 seconds, which inhibited the backflow of blood through the veins.

The researchers found that various aspects of the blood inflow and outflow could be used to distinguish between patients who respond and those who do not respond to therapy.

Moreover, while other imaging technologies, such imaging, use damaging radiation, MRIs are expensive and take a long time, from 30-90 minutes, to perform.

But the new system takes images in less than 10 minutes and uses harmless light and can be performed more frequently than MRI, the researchers said.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Mon, February 12 2018. 13:40 IST