Reunited in England's northwest after two confrontational years on either side of the Barcelona-Real Madrid rivalry, where Mourinho ended Guardiola's three seasons of La Liga dominance, United clearly hoped the feisty Portuguese could again get under the Catalan's skin.
But now in their third seasons in charge, Guardiola and Mourinho's reigns have instead seen a chasm open up with the blue half of Manchester now the dominant side of the city.
Win the Manchester derby on Sunday and City will already be 12 points clear of United just 12 games into the new season, a gap that has gradually widened in each of the past three years.
Despite a difficult first season for Guardiola in English football, City finished that campaign nine points ahead of their City rivals.
Last season the gap jumped to a record 19 between first and second place as City romped to the title with 100 points.
"There is a quality of the work, of the organisation, I think that is untouchable," even Mourinho admitted on Friday.
- Every victory a struggle -
City certainly seem untouchable at the moment. Once again on top of the Premier League, a goal difference of plus 29 to United's plus one tells the story of both sides contrasting fortunes so far this season.
United have at least shown some resilience in recent weeks, coming from behind to beat Newcastle, Bournemouth and most impressively Italian champions Juventus in midweek.
Yet, even then every victory seems a struggle. Only twice have they won by more than one goal all season, to City's 12 multiple-goal victories.
Guardiola also boasts an impressive record against Mourinho, losing just five of their 21 meetings.
But that includes the last one when United came from 2-0 down to stun the Etihad in a 3-2 victory that robbed City of the extra satisfaction of sealing the title against their rivals.
"The point is can we improve enough to catch them next season?" an optimistic Mourinho said at the time.
Fast forward seven months and Mourinho has turned on his superiors at the club for his failure to match City's progression under Guardiola.
"To go to the Juventus level? Barcelona level? Real Madrid level? Manchester City level? How can you reach this level" he complained after losing the first of United's double header with Juve.
"It's not easy. We work with what we have."
Mourinho's argument is that he has not had the backing Guardiola has in the transfer market, despite United spending more than the Abu Dhabi-backed Premier League champions this summer.
The same can be said for Alexis Sanchez. United beat City to his signature from Arsenal in January to much fanfare at the time.
Since those deep pockets have been married with Guardiola's coaching, City are getting much more bang for their buck.
"They are a small club with a small mentality. All they can talk about is Manchester United, that's all they've done and they can't get away from it," said Ferguson, angered at Tevez swapping sides of the Manchester divide.
There was a time with Ferguson in charge when City fans went to derbies more in hope than expectation. Guardiola has put the shoe on the other foot.
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