She was met by her Ghanaian counterpart Rebecca Akufo-Addo and a group of local schoolchildren in yellow and brown uniforms waving the US stars and stripes and the Ghanaian flag.
An AFP reporter at the airport said the former model was smiling and looked relaxed as she was entertained by a troupe of traditional drummers and dancers.
The first lady's office has said the tour will be a "diplomatic and humanitarian visit" that will focus on her #BeBest campaign for "children and their well-being".
It will also "showcase" the work of the US Agency for International Development (USAID), even at a time when her husband's government is looking to slash US aid across the world.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)