Dubai's Emirates is exploring switching some orders for the superjumbo to the smaller A350 in a move that has Airbus looking closely at closing A380 factories sooner than expected, people familiar with the matter told Reuters last week.
Qantas has 12 A380s in its fleet and the spokesman said it would proceed with plans to refurbish the cabins starting in the middle of this year, with the jets set to remain flying with the airline "well into the future".
An Airbus spokesman said the manufacturer had agreed to the "contract amendment" announced by Qantas.
"This change will be reflected in our end January order and delivery tables," the Airbus spokesman said.
The Qantas spokesman declined to comment on the terms of the cancellation.
The A380 has a list price of $445.6 million, but airlines typically receive significant discounts from manufacturers.