New coach Jorge Costa took charge of the side after a disappointing last season where they finished seventh and once again failed to lay their hands on the elusive ISL crown that has eluded Mumbai for the past four seasons.
At the Mumbai Football Arena here, the Islanders would want to start afresh and log full points to gain momentum going ahead.
The 'Islanders' - as they are fondly called -- had a particularly disappointing time last season.
But with new coach Jorge Costa taking over their reins, they will look forward to an improvised show and change of fortunes at the Mumbai Football Arena in suburban Andheri.
Jamshedpur, which finished fifth on the points table last season, also have a new head coach -- Cesar Ferrando who will also be aiming for a positive beginning.
But with two of his best players out from the Tuesday game, the others will have to display something special, if they have to spring a surprise.
Also, Mumbai have not won against Jamshedpur, having drawn and lost a game in their two meetings last season.
The hosts would strive hard to change the narrative this time around.
SQUAD: Mumbai have made several changes to their squad and roped in Indian players like Souvik Chakrabarti, Raynier Fernandes and Subhashish Bose.
Their notable foreign acquisitions include Paulo Machado (Portugal)and striker Rafael Bastos (Brazil).
With Bose, Mumbai have strengthened their defence, which was a definite concern last season, and also included Romanian Lucian Goian, Arnold Issoko (Congo), Souvik Ghosh and Anwar Ali.
With Senegal's Modou Sougou bringing his experience to the table, Mumbai now have a strong mid-field.
If Sougou and Bastos fire in unison, Jamshedpur's defence will come under severe threat.
Mumbai are also expected to display an attacking style of football, which was seen during the pre-season campaign in Thailand where they won three games and drew one.
The hosts also have the solid Amrinder Singh and Kunal Sawant to call upon as goal stoppers.
Mumbai will heave a sigh of relief as Jamshedpur's best bet, Australian World Cup striker Tim Cahill, and senior goal-keeper Subrata Paul will not feature in Tuesday's clash as they have been suspended.
With these two stars missing from the visitors' ranks, Mumbai look to have the edge.
MANAGERS SPEAK: Jamshedpur FC head coach Cesar Ferrando revealed the reasons for the suspension of the two players.
"Paul has a three match ban for the incident in the Super Cup. Cahill has a three-match suspension for an incident which took place for Millwall in the England Second Division and tomorrow his ban ends," Ferrando told reporters at the pre-match media conference.
The coach, however, said that he had a good squad.
"I have a good squad and working very hard and not having three players around is no excuse," he added.
Ferrando also said that the team needed to balance both defence and attack.
"We dont have any style. Defend and attack s what we will play. If you see Barcelona, its good team in attack and defence. We have to balance both aspects," added the Jamshedpur head coach.
It will be Costa's first game in his new role and a win will surely boost his and the side's confidence going ahead into the long tournament.
And according to Costa, it was important to focus on his players.
"It would be good if he (Tim Cahill) can play. I am not that kind of coach who looks at a player's absence.
"It is more important to work at my house - my house means my players - and look at what we can do in the game," Costa said.
HERE'S MUMBAI CITY FC'S 25-MAN SQUAD:
GOALKEEPERS: Amrinder Singh, Kumar Sawant, Ravi Kumar
DEFENDERS: Anwar Ali, Bikramjeet Singh, Davinder Singh, Lucian Goian, Marko Klisura, Arnold Issoko, Sauvik Chakrabarti, Shouvik Ghosh, Subhasish Bose
MIDFIELDERS: Bipin Singh, Matis Mirabaje, Milan Singh, Mohammed Rafique, Modou Sougou, Paulo Machado, Raynier Fernandes, Sanju Pradhan, Sehnaj Singh, Vignesh Dakshinamurthy
FORWARDS: Alen Deory, Pranjal Bhumij, Rafael Bastos
HERE'S JAMSHEDPUR FC'S 25-MAN SQUAD:
GOALKEEPERS: Rafique Ali, Subhasish Roy, Subrata Paul
DEFENDERS: Dhanachandra Singh, Tiri, Karan Amin, Pratik Chowdhary, Raju Gaikwad, Robin Gurung, Sanjay Balmuchu, Yumnam Raju
MIDFIELDERS: Bikash Jairu, Carlos Calvo, Memo, Jerry Mawhmingthanga, Mario Arques, Michael Soosairaj, Mobashir Rahman, Pablo Morgado, Vishal Das
FORWARDS: Farukh Choudhary, Gourav Mukhi, Segio Cidoncha, Sumeet Passi, Tim Cahill