Page 70 - Health Medical Pharma

Elderly cancer survivors face risk of brain metastasis: Study

Elderly survivors of breast cancer, lung cancer, and melanoma face the risk of brain metastasis later in life, claim researchers.Brain metastasis is cancer that spread to the brain from other body parts and therefore considered a secondary brain tumour."As cancer treatments have gotten better and more people are surviving a primary cancer diagnosis, it's important to study secondary cancers, including metastasis to the brain. With an ageing U.S. population, the number of people with brain metastasis is increasing, although sometimes that metastasis does not occur until many years after the initial cancer diagnosis," co-author of the study Barnholtz-Sloan wrote in the study published in the Journal of Cancer Epidemiology, Biomarkers and Prevention."As people are living longer after an initial cancer diagnosis, their 'time at risk' for metastasis is going up. In addition, the majority of primary cancer diagnoses have no standard of care for brain metastasis screening," co-author Ascha ..

Decoded: Why people love to have coffee or beer

Whether you choose a dark roast coffee or hoppy beer in the summer, it may actually depend on how the drink makes you feel rather than how it tastes, reveals a genome-based study.

Nepal witnesses first bird flu death

A 21-year old man has died here after being infected by bird flu, becoming the first-ever patient in the Himalayan nation to succumb to the viral disease, according to a media report. The patient, whose identity has not been revealed, was admitted to a hospital in Kathmandu on March 24 with symptoms of fever and cough. His saliva sample was sent to the National Public Health Laboratory and also to Japan following which it was confirmed that he was suffering from bird flu or avian influenza, My Republica reported on Thursday. Though he was treated, the patient died on March 29, officials from the Ministry of Health and Population (MoHP) said. It was the first-ever death case caused by bird flu in Nepal, they said. The incident was unexpected, Pushpa Chaudhari, secretary at MoHP, said. Bird flu is caused by the highly pathogenic avian influenza A (H5N1) virus or other non-human influenza sub-types (eg H7, H9), according to the World Health Organisation (WHO).

Glenmark Therapeutics inks pact with Otonomy to promote Otiprio in US

Glenmark Pharmaceuticals Friday said its arm Glenmark Therapeutics has inked an agreement with biopharmaceutical firm Otonomy Inc with an exclusive right to promote Otiprio, indicated for treatment of inflammation of the outer ear canal, in the US market. Glenmark Therapeutics Inc, a wholly-owned subsidiary of Glenmark Holding SA, is dedicated to developing and commercialising a franchise of branded products for Glenmark Pharmaceuticals and is focused in the areas of respiratory and dermatology. The agreement provides Glenmark Therapeutics with an exclusive right to promote Otiprio used for the treatment of acute otitis externa (AOE) in patients 6 months of age and older in ear, nose and throat specialist offices in the US and its territories, Glenmark said in a statement. "Financial terms for the multi-year agreement were not disclosed; however, Glenmark Therapeutics will provide Otonomy an annual co-promotion fee and provide reimbursement of a proportion of product support ...

Your sleep habits could be an indicator of heart condition

Researchers claim to have figured out why lack of sleep increases susceptibility to heart diseases.According to the study published in the Journal of Experimental Physiology, chronic short sleep is associated with increased risk of clogged arteries, heart disease, and thus increased morbidity and mortality.Doctors have also identified the patients who might need to change their habits before they develop the disease.In adults who regularly slept fewer than 7 hours per night, the levels of certain microRNAs (molecules that influence whether or not a gene is expressed) were lower.These molecules play a key role in regulating vascular health and thus their levels are now recognised to be sensitive and specific biomarkers of cardiovascular health, inflammation and disease.In other words, a lowered level of these molecules is associated with heart disease, so they could be used as a biomarker to determine who is more susceptible to disease.Researchers tested sedentary, middle-aged adults ..

People love coffee, beer for buzz, not taste: Study

Our preference for coffee or beer is not based on the way the beverages taste, but how they make us feel, according to a study. Scientists from Northwestern University in the US searched for variations in our taste genes that could explain our beverage preferences, because understanding them could indicate ways to intervene in people's diets. They counted the number of servings of bitter and sweet beverages consumed by about 336,000 individuals in the UK Biobank. The researchers did a genome-wide association study of bitter beverage consumption and of sweet beverage consumption. The study, published in the journal Human Molecular Genetics, showed taste preferences for bitter or sweet beverages are not based on variations in our taste genes, but rather genes related to the psychoactive properties of these beverages. "The genetics underlying our preferences are related to the psychoactive components of these drinks," said Marilyn Cornelis, an assistant professor at Northwestern ...

Now vital signs of patients could be monitored by wireless radar

Scientists at the University of Waterloo have developed a radar that can wirelessly monitor the vital signs of patients thus eliminating the dependency on machines.The research was published in the journal IEEE Access.Housed in a device smaller than a cellphone, the new technology records heart and breathing rates using sensitive radar waves that are analysed by sophisticated algorithms embedded in an onboard digital signal processing unit.Researchers developed the system to monitor sleep apnea patients by detecting subtle chest movements instead of connecting them to equipment in labs via numerous cumbersome wires."We take the whole complex process and make it completely wireless. And instead of a clinic, it could be done in the comfort of your own bed and run daily for continuous monitoring," said George Shaker, a cross-appointed professor of electrical and computer engineering at Waterloo.In a study at the Research Institute for Aging, the radar unit was mounted to the ceiling over

Cipla Ltd announces a phased launch of generic cinacalcet hydrochloride tablets in USA

On 03 May 2019

Glenmark Therapeutics Expands Specialty Portfolio With OTIPRIO Co-Promotion Agreement in the U.S. With Otonomy for Acute Otitis Externa Indication

/ -- Glenmark Therapeutics Inc., USA, a wholly-owned subsidiary of Glenmark Holding SA., today announced a co-promotion agreement with Otonomy, Inc. (NASDAQ: OTIC), a biopharmaceutical company dedicated to the development of innovative therapeutics for neurotology. Glenmark Therapeutics is dedicated to developing and commercializing a franchise of branded products for Glenmark Pharmaceuticals and is focused in the areas of respiratory and dermatology. Ryaltris (olopatadine hydrochloride [665 mcg] and mometasone furoate [25 mcg]), formerly GSP 301 Nasal Spray, is the company's leading respiratory pipeline asset and currently under review with the U.S. Food and Drug Administration (FDA) as a treatment of seasonal allergic rhinitis in patients 12 years and older. 'Ryaltris' has been conditionally accepted by the FDA as the brand name. (Logo: https://mma.prnewswire.com/media/451507/PRNE_Glenmark_Logo.jpg ) This agreement provides Glenmark Therapeutics with an exclusive right to promote ..

Alembic Pharma receives USFDA Approval for Olopatadine Hydrochloride Ophthalmic Solution USP, 0.2%.

On 02 May 2019

Concept Medical Inc. Granted 'Breakthrough Device Designation' From FDA for Its MagicTouch Sirolimus Coated Balloon

/ -- Concept Medical Inc. (CMI) has been granted "Breakthrough Device Designation" from the U.S. Food and Drug Administration (FDA) for MagicTouch, its Sirolimus drug-coated balloon (DCB) catheter, for the treatment of coronary in-stent restenosis (ISR). In-stent restenosis (ISR) is the gradual re-narrowing of a stented coronary artery lesion, due to subsequent tissue proliferation at the stented site. ISR is observed in about 10 percent of patients who undergo a drug eluting stent (DES) implantation and in more than 30 percent of patients who undergo bare-metal stent (BMS) implantation. Such patients, who come back with re-clogging of the coronary arteries following an earlier procedure of a bare metal or a drug-eluting stent implant, are candidates for treatment with the MagicTouch. The goal of the FDA "Breakthrough Devices Program" is to provide patients and health-care providers in the U.S. with timely access to these medical devices by speeding up their development, assessment ...

Eating walnuts daily may lower heart disease risk: Study

Eating whole walnuts daily may help lower blood pressure in people at the risk of developing cardiovascular disease (CVD), according to a study. The research, published in the Journal of the American Heart Association, examined the effects of replacing some of the saturated fats in participants' diets with walnuts. Researchers from Pennsylvania State University (Penn State) in the US found that when participants ate whole walnuts daily in combination with lower overall amounts of saturated fat, they had lower central blood pressure. According to the researchers, central pressure is the pressure that is exerted on organs like the heart. This measure, like blood pressure measured in the arm the traditional way, provides information about a person's risk of developing CVD. The study suggests that because walnuts lowered central pressure, their risk of CVD may have also decreased, said Penny Kris-Etherton, Distinguished Professor of Nutrition at Penn State. "When participants ate whole ...

Both mother and baby genes affect birth weight

Recent findings have discovered links between genetic code and birth weight of human beings which explain how mothers' and babies' genes influence birth weight.Scientists have long known that babies who are particularly small at birth have a higher risk of birth complications, and also tend to be more prone than average weight babies to high blood pressure in adulthood.Findings of the study were published in the Journal of Nature Genetics.As part of the study, the researchers looked at genetic information from 230,069 mothers, with the birth weight of one child each, in addition to genetic information and birth weights of 321,223 people across the UK Biobank and the Early Growth Genetics consortium cohorts.A child inherits half their genes from their mother and a half from their father, and the child's own resulting genetic make-up plays a role in birth weight. The paper reveals the complex balance of how both the mother's genes and the baby's genes can influence the baby's growth.The

Adverse events during initial years of life may affect future mental health: Study

Latest findings suggest that the first three years of life may be an especially important period for shaping biological processes that ultimately give rise to mental health conditions.The study claims that the timing of adverse experiences, including poverty, family and financial instability, and abuse, has more powerful effects than the number of such experiences or whether they took place recently.According to the researchers, one of the major unanswered questions in child psychiatry has been 'How do the stressors children experience in the world make them more vulnerable to mental health problems in the future?'"These findings suggest that the first three years of life may be an especially important period for shaping biological processes that ultimately give rise to mental health conditions. If these results are replicated, they imply that prioritizing policies and interventions to children who experienced adversity during those years may help reduce the long-term risk for ...

Eating walnuts daily lowers heart disease risk

Eating a handful of walnuts daily may lower the risk of developing cardiovascular disease (CVD), says a study.

USFDA for voluntary action by Sun Pharma on Dadra plant observations

The United States Food and Drug Administration (USFDA) has given voluntary action indicated classification to drug major Sun Pharmaceutical Industries for its Dadra plant. The health regulator had inspected the company's Dadra facility from March 22 - March 29, 2019; and at the conclusion of the inspection, had issued a Form 483, with 11 observations to the company. In a notification on its website, USFDA has given Voluntary Action Indicated (VAI) classification to the Dadra inspection. As per the USFDA, VAI means that though "objectionable conditions or practices were found, but the agency is not prepared to take or recommend any administrative or regulatory action". In a regulatory filing in April, Sun Pharma had said that it had submitted response to the USFDA within the stipulated timeline and it was committed to addressing the observations promptly. One of the observations by the USFDA related to employees engaged in manufacturing, processing, packaging and holding of a drug ...

Walnuts may help lower blood pressure: Study

Here's another reason to add walnuts to your diet. According to a recent study, when combined with meals low in saturated fats, eating walnuts may help lower blood pressure in people who are at risk for cardiovascular disease.In a randomised, controlled trial, researchers examined the effects of replacing some of the saturated fats in participants' diets with walnuts.They found that when participants ate whole walnuts daily in combination with lower overall amounts of saturated fat, they had lower central blood pressure.According to the researchers, central pressure is the pressure that is exerted on organs like the heart. This measure, like blood pressure measured in the arm the traditional way, provides information about a person's risk of developing cardiovascular disease (CVD).Penny Kris-Etherton, lead researcher of the study, claims that the study suggests that because walnuts lowered central pressure, their risk of CVD may have also decreased."When participants ate whole ...

Living alone may increase risk of mental disorders: Study

Mental disorders are more common in people who live alone, regardless of their age and sex, according to a study. Researchers from the University of Versailles Saint-Quentin-en-Yvelines in France noted that the number of people living alone has increased in recent years due to population ageing, decreasing marriage rates and lowering fertility. Previous studies have investigated the link between living alone and mental disorders but have generally been conducted in elderly populations and are not generalisable to younger adults. The latest study, published in the journal PLOS ONE, used data on 20,500 individuals aged 16-64 living in England who participated in the 1993, 2000, or 2007 National Psychiatric Morbidity Surveys. "Living alone is positively associated with common mental disorders in the general population in England," Louis Jacob from University of Versailles Saint-Quentin-en-Yvelines said in a statement. Whether a person had a common mental disorder (CMD) was assessed using

Premature birth linked to increased risk of chronic kidney disease: Study

As part of a recent study, researchers have discovered links between premature birth and increased risk of chronic kidney disease.According to the study, preterm and early term birth are strong risk factors for the development of chronic kidney disease (CKD) from childhood into mid-adulthood.The researchers claim that given the high levels of preterm birth, and better survival into adulthood, these findings have important public health implications.Preterm birth (before 37 weeks of pregnancy) interrupts kidney development and maturity during late-stage pregnancy, resulting in fewer nephrons forming (filters that remove waste and toxins from the body).Lower nephron number has been associated with the development of high blood pressure and progressive kidney disease later in life, but the long-term risks for adults who were born prematurely remain unclear.As part of the study, a team of researchers set out to investigate the relation between preterm birth and risk of CKD from childhood .

Living alone ups risk of mental disorders

Mental health problems are more common in people living alone regardless of age and sex, says a study.