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Novel treatment may offer promise to TB patients

IANS  |  London 

Researchers have developed a new treatment that could be used to treat hundreds of thousands of patients with (TB).

The study showed that the treatment, which patients will take using an inhaler, works by reducing the bacteria in the lungs causing while also helping the patient's immune system to fight the

"Many cases of are now becoming resistant to existing This new treatment could be used alongside to treat drug-resistant and also possibly reduce the rate of antibiotic resistance resulting from conventional antibiotic treatments," said Sally-Ann Cryan, Associate at the in Ireland (RCSI).

is one of the top 10 causes of death worldwide. Ten million people fell ill with TB and 1.6 million died from the in 2017, according to the World Organization (WHO).

For the study, the team used a spray-drying process and packaged all trans-Retinoic acid (ATRA) solution -- a derivative of Vitamin A -- within safe-for-consumption particles that are small enough to use in an inhaler.

The findings, published in of Pharmaceutics and Biopharmaceutics, demonstrated that these particles efficiently delivered the treatment and significantly reduced TB-causing bacteria and associated lung damage.

"Unfortunately, TB remains a significant problem for world We urgently need innovative treatments like this one if we are to achieve the UN 2030 targets," said Joseph Keane, at Dublin.

There is only one vaccine for TB, developed in 1921, which is unreliable in preventing the most common form of TB, and is not suitable in all patient groups.

The vaccine works best against specific forms of TB and is usually given to infants in at-risk populations.

There were 558,000 new cases with resistance to the most effective first-line antibiotic, among which 82 per cent were resistant to multiple antibiotics, estimated the WHO.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Wed, January 09 2019. 18:08 IST