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'Cell therapy may replace need for kidney transplants'

Press Trust of India  |  Washington 

Regenerating damaged tissues using therapeutic cells may prove to be a promising new approach to treat chronic disease, scientists say.

Researchers from the Wake (WFIRM) in the US found that harnessing the unique properties of human amniotic fluid-derived could potentially help recover organ function in a pre-clinical model of disease.

"Our results indicate that this type of stem cell could be used as an off the shelf universal cell source and may provide an alternative therapeutic strategy for patients suffering from this chronic and debilitating disease," said James J Yoo, a at WFIRM.

Amniotic fluid-derived can be used as a universal cell source because they have the ability to become different cell types as well as the ability to be anti-inflammatory, making them a potential source for regeneration.

Unlike pluripotent and adult stem cells, amniotic fluid-derived are not as likely to provoke an immune system response.

Their use does not lead to risks of or ethical concerns, as with embryonic stem cells, researchers said.

The study, published in the journal Part A, found that amniotic fluid stem cells injected into a diseased in a pre-clinical model led to improvement of kidney function based on measured waste levels after 10 weeks.

Biopsy findings showed reduced damage to the cluster of capillaries where are filtered from the blood.

"Our studies demonstrate that treatment with amniotic fluid stem cells had positive effects on functional improvement and structural recovery of the kidney," said WFIRM

is a worldwide public health problem and can manifest in acute and chronic symptoms, researchers said.

is the only definitive treatment method that restores kidney function, but has its own challenges with rejection and life-long

There also are not enough donor organs to meet demand.

"It remains to be seen whether injecting more cells or more efficient engraftment of the infused cells enhances improvement of organ function," said Sunil George, a WFIRM research fellow.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, March 15 2019. 17:50 IST
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