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Can cell therapy replace need for kidney transplant?

IANS  |  New York 

Researchers are working on a promising approach for treatment of chronic disease by of damaged tissues using therapeutic cells.

By harnessing the unique properties of human amniotic fluid-derived stem cells, the team, from the for (WFIRM), showed that the cells could potentially help recover organ function in a pre-clinical model of disease.

"Our results indicate that this type of stem cell could be used as an off the shelf universal cell source and may provide an alternative therapeutic strategy for patients suffering from this chronic and debilitating disease," said James J. Yoo, at the WFIRM, US.

According to researchers, amniotic fluid-derived can be used as a universal cell source because they have the ability to become different cell types and are anti-inflammatory, making them a potential source for

Unlike pluripotent and adult stem cells, amniotic fluid-derived are not as likely to provoke an immune system response. Additionally, their use does not lead to risks of or ethical concerns, they added.

For the study, published in the journal Part A, the team found that amniotic fluid injected into a diseased in a pre-clinical model led to improvement of kidney function based on measured waste levels after 10 weeks.

Biopsy findings showed reduced damage to the cluster of capillaries where are filtered from the blood.

"Our studies demonstrate that treatment with amniotic fluid stem cells had positive effects on functional improvement and structural recovery of the kidney," said Anthony Atala, from the institution.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, March 15 2019. 16:00 IST