In one incident, armed gunmen on motorcycles opened fire on people sitting at a tea stall close to a well known madrasa.
DIG East zone, Shahid Hayat confirmed that atleast five people including students of the madrasa had been killed in the incident while they were about three others injured.
"Condition of two of the injured is critical," he said.
In another incident of target killing near a college, armed men on motorcycles killed three persons travelling in a car, one of them is said to be the editor of a weekly magazine.
Police said 17 people were killed in the latest spate of violence in the city.
The killings come at a time when an International Defence Exhibition is being held in the city and Chief Minister of Bihar Nitish Kumar is also visiting with a high level delegation.
Interestingly, in most of the incidents today the killings were carried out by gunmen on motorcycles although the Sindh provincial government last night imposed a ban on pillion riding ahead of the Islamic month of Muharram.
Even in the provincial capital city of Baluchistan province, members of the minority Hazara Shia community were targeted again with three killed in two different incidents.
Soon after the shooting near the madrasa, angry students came out on the roads and a spokesman for the Ahle Sunnat Wal Jamaat said the government had failed miserably to provide security and safety to citizens.
Earlier, target killings were reported in different areas of the city with two men shot dead in Korangi.
One person in a car was killed while another was shot dead in Mujahid Colony in Nazimabad.
Interior Minister Rehman Malik gave details regarding violence in Karachi to the National Assembly and said that a total of 1,363 people have lost their lives at the hands of target killers during the past five years.
Giving a breakdown of the figure, Malik had said that 104 people had been killed in year 2008, 160 in 2009, 373 in 2010, 478 in 2011 and 248 so far in 2012.
However, the figures given by independent organisations including the Human Rights commission of Pakistan put the figure of those killed this year much higher.