The supermodel, born in Bergisch Gladbach, has been selected to lead the live broadcast in November in Frankfurt, Germany, reported Aceshowbiz.
"I'm honored to host the 2012 MTV EMAs in its return to my home country of Germany. The MTV EMA is one of the biggest nights in global music, fashion and culture, and I'm thrilled to play a part in bringing this one-of-a-kind show to audiences all over the world.
We're going to have a blast!" Klum said in a statement.
The 2012 MTV Europe Music Awards will take place at the Festhalle in Frankfurt on Sunday, November 11. MTV channels around the world will broadcast it live.
Nominees for this year's ceremony have been announced with Rihanna and Taylor Swift leading the pack at six and five nods respectively. Presenters and performers will be announced at a later date.