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IIT-R finds new method to detect breast, ovarian cancer

Press Trust of India  |  Roorkee 

Researchers at the Indian Institute of Technology, Roorkee have found a new method to detect breast and ovarian cancer, responsible for one fifth of cancer-related deaths worldwide.

The research published in the journal, 'FASEB Bioadvances' details the use of whole saliva as a body fluid for early detection of breast and ovarian cancers, as opposed to the traditional method of using blood samples.

Making a breakthrough, the research team led by from the Department at IIT Roorkee have identified certain proteins present in the saliva, which act as potential biomarkers indicative of breast and ovarian metastasis.

The team compared samples from healthy individuals against samples collected from stage IV breast and ovarian patients and ovarian patients who had undergone at least 3 cycles of neoadjuvant

Due to the heterogeneous and asymptomatic nature of breast and ovarian cancers, their early detection has been difficult using traditional methods such as mammography, blood flow patterns by colour flow Doppler and transvaginal examination, due to high diagnostic costs and exposure," Ambatipudi said.

"Our attempt was to utilize saliva as a non-invasive sample source to identify specific protein biomarkers, which indicate breast & metastasis. In patients who have undergone three cycles of chemotherapy, the salivary proteins can also act as an indicator of the patient's response to

Although it is essential to clinically validate these proteins in a large cohort of subjects but the results of the present study serve as an initial step towards development of saliva-based clinical tests, he added.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Tue, April 16 2019. 14:55 IST