The Nikkei average tumbled 4.80 percent to 37,919.55 while the broader Topix index closed 3.47 percent lower at 2,645.94.
Automakers Honda Motor, Toyota and Nissan plunged 6-8 percent after the dollar fell from over 146 yen to under 143 yen.
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Industrial production in Japan was down a seasonally adjusted 3.3 percent on month in August, the Ministry of Economy, Trade and Industry said on Monday. On a yearly basis, output slumped 4.9 percent.
The total value of retail sales in Japan was up a seasonally adjusted 0.8 percent on month in August, the Ministry of Economy, Trade and Industry said on Monday - coming in at 13.772 trillion yen.
That's up from 0.2 percent in July and 0.6 percent in June. On a yearly basis, retail sales advanced 2.8 percent.
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