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Antidepressants during pregnancy may not up autism risk in children: Study

There has been a long-standing debate about expectant mothers taking antidepressants

IANS  |  Washington 

Progesterone may not help women with miscarriage history

An increased risk of among children of women who took during may actually be the result of maternal mental illnesses, according to new research.

Up to 15 per cent of women have depression during and are a popular treatment choice for those with depression, Xinhua news agency reported.

However, there has been a long-standing debate about whether expectant mothers with depression should take

In a paper published by the US journal JAMA Pediatrics, Antonia Mezzacappa of the Bicetre University in France and colleagues reviewed and analysed 10 studies that have explored associations between fetal exposure to and spectrum disorders (ASDs).

"Based on our meta-analyses, there is a significant association between ASDs and prenatal maternal use of However, it appears to be more consistent during pre-than each trimester," the study noted.

The study also found that the association was weaker when past maternal illness of the was controlled for.

As a result, the study said the public implications of the possible risk for ASDs as a result of antidepressant exposure during are "difficult to assert or to refute, especially as we also observed an association with preconception exposure."

"The increased risk for ASDs in children exposed in utero could well be related to maternal depression or other psychiatric disorders rather than to antidepressant medications per se," it concluded.

Irene Petersen, a researcher at the University College London, who was not involved in the study, said it's tricky to study the exposure on in and the risk of ASDs, as the effects of drug treatment are often difficult to be separated from other risk factors such as maternal illnesses.

"The findings from this review suggest that antidepressant treatment may be a 'marker' of women who may have an elevated risk of giving birth to a child with ASD," Petersen said.

"However, I would be very cautious about reaching a conclusion that treatment in itself is causing With the existing evidence, we still cannot exclude the possibility that it is maternal illnesses linked to ASD -- and not the antidepressants," he added.

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Antidepressants during pregnancy may not up autism risk in children: Study

There has been a long-standing debate about expectant mothers taking antidepressants

There has been a long-standing debate about expectant mothers taking antidepressants
An increased risk of among children of women who took during may actually be the result of maternal mental illnesses, according to new research.

Up to 15 per cent of women have depression during and are a popular treatment choice for those with depression, Xinhua news agency reported.

However, there has been a long-standing debate about whether expectant mothers with depression should take

In a paper published by the US journal JAMA Pediatrics, Antonia Mezzacappa of the Bicetre University in France and colleagues reviewed and analysed 10 studies that have explored associations between fetal exposure to and spectrum disorders (ASDs).

"Based on our meta-analyses, there is a significant association between ASDs and prenatal maternal use of However, it appears to be more consistent during pre-than each trimester," the study noted.

The study also found that the association was weaker when past maternal illness of the was controlled for.

As a result, the study said the public implications of the possible risk for ASDs as a result of antidepressant exposure during are "difficult to assert or to refute, especially as we also observed an association with preconception exposure."

"The increased risk for ASDs in children exposed in utero could well be related to maternal depression or other psychiatric disorders rather than to antidepressant medications per se," it concluded.

Irene Petersen, a researcher at the University College London, who was not involved in the study, said it's tricky to study the exposure on in and the risk of ASDs, as the effects of drug treatment are often difficult to be separated from other risk factors such as maternal illnesses.

"The findings from this review suggest that antidepressant treatment may be a 'marker' of women who may have an elevated risk of giving birth to a child with ASD," Petersen said.

"However, I would be very cautious about reaching a conclusion that treatment in itself is causing With the existing evidence, we still cannot exclude the possibility that it is maternal illnesses linked to ASD -- and not the antidepressants," he added.
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Business Standard
177 22

Antidepressants during pregnancy may not up autism risk in children: Study

There has been a long-standing debate about expectant mothers taking antidepressants

An increased risk of among children of women who took during may actually be the result of maternal mental illnesses, according to new research.

Up to 15 per cent of women have depression during and are a popular treatment choice for those with depression, Xinhua news agency reported.

However, there has been a long-standing debate about whether expectant mothers with depression should take

In a paper published by the US journal JAMA Pediatrics, Antonia Mezzacappa of the Bicetre University in France and colleagues reviewed and analysed 10 studies that have explored associations between fetal exposure to and spectrum disorders (ASDs).

"Based on our meta-analyses, there is a significant association between ASDs and prenatal maternal use of However, it appears to be more consistent during pre-than each trimester," the study noted.

The study also found that the association was weaker when past maternal illness of the was controlled for.

As a result, the study said the public implications of the possible risk for ASDs as a result of antidepressant exposure during are "difficult to assert or to refute, especially as we also observed an association with preconception exposure."

"The increased risk for ASDs in children exposed in utero could well be related to maternal depression or other psychiatric disorders rather than to antidepressant medications per se," it concluded.

Irene Petersen, a researcher at the University College London, who was not involved in the study, said it's tricky to study the exposure on in and the risk of ASDs, as the effects of drug treatment are often difficult to be separated from other risk factors such as maternal illnesses.

"The findings from this review suggest that antidepressant treatment may be a 'marker' of women who may have an elevated risk of giving birth to a child with ASD," Petersen said.

"However, I would be very cautious about reaching a conclusion that treatment in itself is causing With the existing evidence, we still cannot exclude the possibility that it is maternal illnesses linked to ASD -- and not the antidepressants," he added.

image
Business Standard
177 22