"Today's sanctions target the North Korean military and regime officials engaged in flagrant abuses of human rights," Xinhua quoted US Treasury Secretary Steven Mnuchin as saying.
Pyongyang's financial facilitators "who attempt to keep the regime afloat with foreign currency earned through forced labour operations" were also targeted, Mnuchin added.
Among the sanctioned individuals were North Korea's military security officials and Labour Minister Jong Yong Su. North Korea's consul general in Shenyang, China, and a diplomat at its embassy in Vietnam were also targeted.
As a result of the saction, any property or interests of the designated persons in the US will be blocked and transactions by Americans involving these persons are generally prohibited.
The new moves came a month after the US Department of Treasury slapped sanctions on eight banks and 26 individuals linked to North Korea financial networks in response to the country's ongoing development of weapons of mass destruction.
The North Korea successfully tested two intercontinental ballistic missile and a hydrogen bomb this year, triggering two new economic sanctions by the UN Security Council.