Brushing teeth well can reduce colorectal cancer risk

Two new studies have revealed that gut microbes known as fusobacteria, which are found in the mouth, stimulate bad immune responses and turn on growth genes to generate colorectal tumors.

The findings could lead to more effective strategies for the early diagnosis, prevention, and treatment of colorectal cancer.

"Fusobacteria may provide not only a new way to group or describe colon cancers but also, more importantly, a new perspective on how to target pathways to halt tumor growth and spread," senior study author Wendy Garrett of the Harvard School of Public and the Dana-Farber Cancer Institute, said.

Colorectal cancer is the second leading cause of cancer-related death in the United States.

Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients. But until now, it was not known whether these microbes directly contribute to the formation of tumors.

In one of the new studies, Garrett, Matthew Meyerson of the Dana-Farber Cancer Institute, and their collaborators found that fusobacteria are prevalent in human adenomas-benign tumors that can become malignant over time-suggesting that these microbes contribute to early stages of tumor formation.

In a mouse model of colorectal cancer, these bacteria accelerated the formation of tumors by attracting immune cells called myeloid cells, which invade tumors and stimulate inflammatory responses that can cause cancer.

In the second study, Yiping Han of Case Western Reserve University School of Dental Medicine and her collaborators discovered that fusobacteria rely on a molecule called Fusobacterium adhesin A (FadA), which is found on the surface of these bacterial cells, to attach to and invade human colorectal cancer cells.

FadA then turns on cancer growth genes and stimulates inflammatory responses in these cells and promotes tumor formation.

Han and her team also found that FadA levels were much higher in tissues from patients with adenomas and colorectal cancer compared with healthy individuals.

Moreover, they identified a compound that can prevent FadA's effects on cancer cells.

The study is published in the journal Cell Host and Microbe.

image
Business Standard
177 22
Business Standard

Brushing teeth well can reduce colorectal cancer risk

ANI  |  Washington 

Two new studies have revealed that gut microbes known as fusobacteria, which are found in the mouth, stimulate bad immune responses and turn on growth genes to generate colorectal tumors.

The findings could lead to more effective strategies for the early diagnosis, prevention, and treatment of colorectal cancer.

"Fusobacteria may provide not only a new way to group or describe colon cancers but also, more importantly, a new perspective on how to target pathways to halt tumor growth and spread," senior study author Wendy Garrett of the Harvard School of Public and the Dana-Farber Cancer Institute, said.

Colorectal cancer is the second leading cause of cancer-related death in the United States.

Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients. But until now, it was not known whether these microbes directly contribute to the formation of tumors.

In one of the new studies, Garrett, Matthew Meyerson of the Dana-Farber Cancer Institute, and their collaborators found that fusobacteria are prevalent in human adenomas-benign tumors that can become malignant over time-suggesting that these microbes contribute to early stages of tumor formation.

In a mouse model of colorectal cancer, these bacteria accelerated the formation of tumors by attracting immune cells called myeloid cells, which invade tumors and stimulate inflammatory responses that can cause cancer.

In the second study, Yiping Han of Case Western Reserve University School of Dental Medicine and her collaborators discovered that fusobacteria rely on a molecule called Fusobacterium adhesin A (FadA), which is found on the surface of these bacterial cells, to attach to and invade human colorectal cancer cells.

FadA then turns on cancer growth genes and stimulates inflammatory responses in these cells and promotes tumor formation.

Han and her team also found that FadA levels were much higher in tissues from patients with adenomas and colorectal cancer compared with healthy individuals.

Moreover, they identified a compound that can prevent FadA's effects on cancer cells.

The study is published in the journal Cell Host and Microbe.

RECOMMENDED FOR YOU

Brushing teeth well can reduce colorectal cancer risk

Two new studies have revealed that gut microbes known as fusobacteria, which are found in the mouth, stimulate bad immune responses and turn on cancer growth genes to generate colorectal tumors.The findings could lead to more effective strategies for the early diagnosis, prevention, and treatment of colorectal cancer."Fusobacteria may provide not only a new way to group or describe colon cancers but also, more importantly, a new perspective on how to target pathways to halt tumor growth and spread," senior study author Wendy Garrett of the Harvard School of Public Health and the Dana-Farber Cancer Institute, said.Colorectal cancer is the second leading cause of cancer-related death in the United States.Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients. But until now, it was not known whether these microbes directly contribute to the formation of tumors.In one of the new studies, Garrett, Matthew Meyerson of the ...

Two new studies have revealed that gut microbes known as fusobacteria, which are found in the mouth, stimulate bad immune responses and turn on growth genes to generate colorectal tumors.

The findings could lead to more effective strategies for the early diagnosis, prevention, and treatment of colorectal cancer.

"Fusobacteria may provide not only a new way to group or describe colon cancers but also, more importantly, a new perspective on how to target pathways to halt tumor growth and spread," senior study author Wendy Garrett of the Harvard School of Public and the Dana-Farber Cancer Institute, said.

Colorectal cancer is the second leading cause of cancer-related death in the United States.

Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients. But until now, it was not known whether these microbes directly contribute to the formation of tumors.

In one of the new studies, Garrett, Matthew Meyerson of the Dana-Farber Cancer Institute, and their collaborators found that fusobacteria are prevalent in human adenomas-benign tumors that can become malignant over time-suggesting that these microbes contribute to early stages of tumor formation.

In a mouse model of colorectal cancer, these bacteria accelerated the formation of tumors by attracting immune cells called myeloid cells, which invade tumors and stimulate inflammatory responses that can cause cancer.

In the second study, Yiping Han of Case Western Reserve University School of Dental Medicine and her collaborators discovered that fusobacteria rely on a molecule called Fusobacterium adhesin A (FadA), which is found on the surface of these bacterial cells, to attach to and invade human colorectal cancer cells.

FadA then turns on cancer growth genes and stimulates inflammatory responses in these cells and promotes tumor formation.

Han and her team also found that FadA levels were much higher in tissues from patients with adenomas and colorectal cancer compared with healthy individuals.

Moreover, they identified a compound that can prevent FadA's effects on cancer cells.

The study is published in the journal Cell Host and Microbe.

image
Business Standard
177 22
Widgets Magazine

More News

  • Infra giants return to highways sector Infra giants return to highways sector
  • Vishal Sikka Is Infosys underpriced compared with TCS?
Widgets Magazine
Widgets Magazine

Upgrade To Premium Services

Welcome User

Business Standard is happy to inform you of the launch of "Business Standard Premium Services"

As a premium subscriber you get an across device unfettered access to a range of services which include:

  • Access Exclusive content - articles, features & opinion pieces
  • Weekly Industry/Genre specific newsletters - Choose multiple industries/genres
  • Access to 17 plus years of content archives
  • Set Stock price alerts for your portfolio and watch list and get them delivered to your e-mail box
  • End of day news alerts on 5 companies (via email)
  • NEW: Get seamless access to WSJ.com at a great price. No additional sign-up required.
 

Premium Services

In Partnership with

 

Dear Guest,

 

Welcome to the premium services of Business Standard brought to you courtesy FIS.
Kindly visit the Manage my subscription page to discover the benefits of this programme.

Enjoy Reading!
Team Business Standard