Foreign Secretary Jalil Abbas Jilani will also be part of Khar's delegation, said a statement from the Foreign Office.
Though the statement did not give details of the agenda for the meetings, the interactions will focus on the drawdown of foreign forces in Afghanistan and Pakistan's role in the peace process in the war-torn country.
During her meeting with Clinton, Khar is expected to "exchange views on the way forward to achieve the common objectives of peace and stability in the region," the statement said.
While in Brussels, Khar will hold discussions with her Belgian counterpart Didier Reynders on bilateral relations.
She will meet the European Union's High Representative, Lady Catherine Ashton, NATO Secretary General Anders Fogh Rasmussen and EU Trade Commissioner, Karel De Gucht.
Her engagements include talks at the North Atlantic Council and Carnegie Endowment Europe.
Khar's delegation will also interact with the Foreign Affairs Committee of the European Parliament.