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Dietary changes help reduce inflammatory bowel disease in mice, claims study


A recent study conducted on mice has found that dietary modification helps in treating (IBD).

University of researchers published a paper in proving that changing the diet to a fasting-mimicking diet (FMD) where the mice were only fed plant-based foods over a period of several days to trick the body into entering a period of fasting which in turn changed the gut microbiota that reduced the pathology.

FMD has previously shown a reduction of the symptoms of several chronic illnesses, like and

During the study, researchers induced symptoms and pathology in mice by feeding them dextran sodium sulphate (DSS) which causes in mice. The mice after this received multiple FMD cycles involving Another group of mice were infected by DSS but underwent water only fasting. Mice that received FMD showed reduced symptoms, increased stem cell numbers and reversed intestinal pathology which was caused by DSS whereas mice that were on water-only fasting increased regenerative and reduced but did not reverse pathology.

"Because of its content, the diet is facilitating changes in the microbiota, including repopulation or major changes in the population of Lactobacillus," says

"You wouldn't think mice would have that much Lactobacillus, but they were given a human diet so it seems to promote the growth of bacteria normally associated with a healthy human vegan diet," continues Longo.

Looking ahead the researchers are finalizing the protocol for a randomized clinical trial of a modified FMD in humans to see if the microbiota changes and produces any effects on IBD pathology.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, March 15 2019. 15:38 IST