Ambiguity in the results of genetic testing for breast cancer does not cause patients to worry more about their cancer risk, suggest researchers.
The study has been published in JCO Precision Oncology.
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"Genetic testing is becoming increasingly more complex, but increasingly more precise. This has led to some ambiguity in test results. The challenge is incorporating this information into the treatment decision without causing unnecessary worry," said lead study author Steven J. Katz of the University of Michigan.
Initially, genetic testing for breast cancer focused exclusively on BRCA1 and BRCA2 genes. Now, newer multigene panel tests look for abnormalities in a dozen or more different genes that play some role in breast cancer risk. By testing more genes, it's more likely a patient will have a positive test or a variant of unknown significance - in other words, something is out of the ordinary but doctors do not know how that impacts cancer risk.
The concern is that this greater variation could lead patients to worry too much about their risk of breast cancer recurrence when the genetic testing results are ambiguous.
Researchers surveyed 1,063 women treated for early stage breast cancer who had received genetic testing between the years 2013-2015, the period in which panel testing became more popular. About 60 per cent of the patients were tested only for BRCA1 and BRCA2, while 40 per cent had the multigene panel test. Patients were asked how much and how often they worried about their cancer coming back and the impact that worry had on their life.
Overall, 11 per cent of patients reported cancer worry had high impact on their life and 15 per cent worried often or almost always. Neither the impact nor the frequency of worry varied substantially based on the type of genetic testing or the test results.
"These findings are reassuring," Katz said. "We found that patients did not overreact whether they got the newer panel testing or BRCA-only testing, and they did not overreact to the test results. Their future cancer worry was not different whether they had a negative test or variant of unknown significance."
Virtually all of the patients surveyed received some form of genetic counseling.
"Genetic counseling is essential to maximise the benefit of testing for patients and their families," said senior study author Allison W. Kurian. "But timely counseling after diagnosis of breast cancer is increasingly a challenge because more patients are getting tested and the results are more complex.
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