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Study renders insights into genetic abnormalities leading to multiple myeloma

ANI  |  New Delhi [India] 

In India, incidence of affects 1.8 per cent in a population of 100,000. Approximately, 50,000 new cases of are diagnosed each year.

A recent study conducted by CORE Diagnostics reveal that genetic abnormalities are more prevalent among younger median age of 50 years to 70 years, which forms 65 per cent of total cases.

Out of 1001 cases, 37 per cent were found positive for various abnormalities like; Del13q(RB1), Del17p(TP53), t (4;14), t(11;14), t(14;16), 1q, Hypodiploidy and Hyperdipolidy etc.

The study aimed to find out the frequency of Cytogenetic aberrations in multiple myeloma patients in Indian perspective. The retrospective observational study included 1001 patients falling in the age bracket of 21-90 years and was carried on over a course of three years from January 2015 to January 2018 at CORE Diagnostics.

The study was conducted using Plasma Cell Enrichment Technique, which is a more accurate mechanism for separating plasma cells from other cells during testing. The test has revolutionized genetic analysis and enabled precise determination of the presence and frequency of genetic abnormalities.

"Majority of the studies on genetic aberrations in multiple myeloma include western population. Our study includes 1001 Indian patients, which would help in better understanding of genetic abnormalities among Indian population. We used Plasma Cell Enrichment Technique for the study which is a path breaking technique available at only a handful of centers in The results will definitely prove to be beneficial to understand the in a better way", said Dr. Mohit Bhardwaj, PhD Lead Cytogeneticist, CORE Diagnostics.

Multiple myeloma is also known as plasma cell myeloma and is a of plasma cells, a type of white blood cell. Usually, the does not exhibit any major symptoms initially and symptoms like bone pain, bleeding, and generally occur at a later stage.

The cause of this ailment is still unknown; however, the risk factors include drinking alcohol, obesity, exposure, family history and certain

Multiple myeloma involves abnormal plasma cells producing abnormal which can cause kidney problems and overly thick blood. The plasma cells also sometimes form a mass in the bone marrow or soft tissue. When only one mass is present, it is known as a while more than one is known as multiple myeloma.

Multiple myeloma is diagnosed using blood or urine samples which help in finding abnormal Besides this, bone marrow biopsy helps in finding cancerous plasma cells and in finding bone lesions. Although, considered to be a treatable disease, multiple myeloma is generally incurable.

Relief can be derived through chemotherapy, steroids, thalidomide or lenalidomide and stem cell transplant. Bisphosphonates and therapy is also used to reduce from bone lesions.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Tue, March 13 2018. 10:22 IST
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