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Autism, schizophrenia share gene activity in brain

IANS  |  New York 

Researchers have found that like autism, and share some physical characteristics at the molecular level, specifically, patterns of in the brain.

The findings, published in the journal Science, raise hope for better diagnosis and therapies for people with major

"These findings provide a molecular, pathological signature of these disorders, which is a large step forward," said Daniel Geschwind, at the University of California,

"The major challenge now is to understand how these changes arose," Geschwind said.

Researchers know that certain variations in genetic material put people at risk for psychiatric disorders, but DNA alone does not tell the whole story.

Every cell in the body contains the same DNA. RNA molecules, on the other hand, play a role in in different parts of the body, by "reading" the instructions contained within the DNA.

The researchers reasoned that taking a close look at the RNA in human brain tissue would provide a molecular profile of these

They analysed the RNA in 700 tissue samples from the brains of patients who had autism, schizophrenia, bipolar disorder, or alcohol abuse disorder, comparing them to samples from brains without psychiatric disorders.

The molecular pathology showed significant overlap between distinct disorders, such as and schizophrenia, but also specificity, with major showing molecular changes not seen in the other disorders.

The findings suggest that are more similar at molecular level than their characteristic symptoms indicate.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, February 09 2018. 19:20 IST