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Common toothpaste ingredient linked to colon cancer

IANS  |  New York 

Using triclosan, an antibacterial and antifungal agent found in hand soaps and toothpastes among other consumer products, can potentially cause and cancer, finds a study on mice.

The study, reported in Science Translational Medicine, suggests that short-time treatment with low-dose caused low-grade colonic inflammation, and development of and colitis-associated in mice.

"These results, for the first time, suggest that could have adverse effects on gut health," said Guodong Zhang at the University of Massachusetts-Amherst, US.

Previous research has suggested that can have toxic effects at high doses, but the effects of lower concentrations that a person might be exposed to remain unclear.

For the new study, the team fed mice with containing various concentrations of triclosan for three weeks.

The results showed that mice treated with a concentration of triclosan that reflects the concentrations reported in human blood samples displayed more compared to control animals.

Furthermore, triclosan exposure increased the severity of in mouse models of -- an effect that persisted even when low doses of the were administered.

Triclosan treatment also increased size and reduced survival in a separate group of rodents with

Interestingly, triclosan also reduced the diversity of commensal bacteria in the gut of mice, and germ-free mice were protected from the harmful effects, suggesting its pro-inflammatory actions may arise due to alteration of the gut microbiome.

The researchers stressed that further studies should assess the impact of triclosan on human gut health, and determine whether individuals with or could be more vulnerable to any adverse effects.

"Because this compound is so widely used, our study suggests that there is an urgent need to further evaluate the impact of triclosan exposure on gut in preparation for the potential establishment of further regulatory policies," said Haixia Yang, a postdoctoral fellow at the varsity.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Thu, May 31 2018. 16:22 IST