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Novel DNA vaccine against Ebola virus safe, effective

IANS  |  New York 

Scientists, including one of Indian-origin, have found that the novel synthetic DNA vaccine is safe against and offers a long-term alternative to traditional

The team, from The in Philadelphia, US, optimised a shorter, dose-sparing, immunisation regimen and simplified vaccine that can be directly administered into the skin. They targeted a surface protein called glycoprotein.

This new approach induced rapid and protective immunity from challenges.

Importantly, the approach showed strong immune responses one year after the last dose, supporting the long-term immunogenicity of the vaccine -- a particularly challenging area for

"Synthetic non-viral based allows for rapid vaccine development by delivery directly into the skin, resulting in consistent, potent and rapid immunity compared to traditional vaccine approaches," said David B. Weiner, of

"An anti-virus DNA vaccine like this may provide an for protection, and we are excited to see what future studies will unveil," he added.

In the study, published in the Journal of Infectious Diseases, the team detected antibody levels were equal or higher to those reported for other currently being evaluated in the clinic.

"The success of intradermal delivery of a low-dose regimen is very encouraging," said Ami Patel, Ph.D., in the "The ultimate goal of our work is to create effective and safe vaccines that are optimised for field use in at-risk areas."

disease is a serious and that can cause fever, headache, muscle pain, weakness, fatigue, diarrhoea, vomiting, and haemorrhage (severe bleeding).

First discovered in humans in 1976 in the Democratic Republic of the Congo, the largest outbreak occurred in from 2014 to 2016, which claimed more than 11,000 lives, according to the World Organization.

The death rate is about 50 per cent and the virus is spread by contact with contaminated body fluids, including blood and semen.

While there are no licensed treatments available for disease yet, multiple are being developed.

--IANS

rt/mag/sed

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Thu, October 11 2018. 14:10 IST
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