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Novel humanised mouse model to study hepatitis B

IANS  |  Beijing 

Researchers have developed a humanised mouse model to study development induced by B virus

Developing an ideal animal model of B virus (HBV) is difficult because the virus has an extremely narrow host range and almost exclusively infects humans, reported.

Previous studies show that mesenchymal from human bone marrow (hBMSCs) have the potential to differentiate into hepatocyte-like cells in vitro and continue to maintain essential hepatocyte functions in vivo after being transplanted into host mouse livers.

Hepatocytes make up 70 to 85 per cent of the mass, the researchers from and Zhejiang University, said.

For the study, the research team transplanted hBMSCs into mice.

The mice show robust differentiation and proliferation of functional human hepatocytes and multiple immune cells, according to the research paper published in of Gut.

After infection, the humanised mice developed and showed progression to chronic and

The researchers said the new humanised mouse model recapitulates the liver induced by human infection, providing opportunities for better understanding the immune pathophysiology of and testing promising in vivo.

According to the World Health Organisation, an estimated 257 million people are living with HBV infection, which can cause chronic and put people at high risk of death from cirrhosis and



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Tue, February 12 2019. 15:58 IST