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Oral bacteria may up risk of pancreatic cancer

IANS  |  London 

The presence of oral bacteria in is associated with the severity of the tumour, a new study suggests.

According to the researcher, the results can help to reappraise the role of bacteria in the development of If further studies show that the bacteria actually affects the pathological process, it could lead to new therapeutic strategies using antibacterial agents.

"We were surprised to find oral bacteria in the pancreas, but it wasn't totally unexpected. The bacteria we identified has already been shown in an earlier, smaller study to be higher in the saliva of patients with pancreatic cancer," said from the Karolinska Institutet in

Not all are cancerous. For instance there are so-called (pancreatic cysts), many of which are benign. A few can, however, become cancerous, the said.

"We find most bacteria at the stage where the are starting to show signs of cancer," Chen said.

"What we hope is that this can be used as a biomarker for the early identification of the cancerous that need to be surgically removed to cure .." she added.

For the study, published in the journal Gut, the team examined the presence of bacterial DNA in fluid from in 105 patients and compared the type and severity of the tumours.

The results showed that the fluid from the cysts with high-grade dysplasia and contained much more bacterial DNA than that from

To identify the bacteria, the researchers sequenced the DNA of 35 of the samples that had high amounts of bacterial DNA.

They found large variations in the bacterial composition between different individuals, but also a greater presence of certain oral bacteria in fluid and tissue from cysts with high-grade dysplasia and

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(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, March 15 2019. 18:40 IST
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