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Thus tiny cell is good news for cancer survivors (Health Feature)

IANS  |  Bengaluru 

A at the for Research in Reproductive Health (NIRRH) in -- an institute under the (ICMR) -- says a new type of identified by her team can help restore fertility in men and women who have undergone treatment for

treatment, or "oncotherapy", that involves use of and chemicals, renders patients infertile as an unwanted side effect and, while cured of cancer, they cannot beget children.

Though women are born with a lifetime reserve of "oocytes" ( immature eggs), these are wiped out by oncotherapy. In males, the testes responsible for the production of sperms, stop making them following treatment.

Currently accepted approaches for fertility preservation require male patients to deposit their sperm in "cryo-banks" before beginning for later use. Similarly women, wanting to have children, must have their eggs or embryos "cryopreserved" for use after oncotherapy.

"Such approaches are invasive, expensive, technically challenging and depend on assisted reproductive technologies," reports in the latest issue of of Medical Research, the flagship journal of ICMR.

According to the report, there is now a way out. Bhartiya says research by her team over the years led to identification of a novel population of "Very Small Embryonic-Like (VSELs)", in testis (in males) and ovaries (in females).

Being "quiescent" by nature, these primitive (VSELs) survive and therefore can offer survivors options to have children without having to bank their sperms or embryos prior to oncotherapy, says the report.

"The VSELs have remained elusive over decades due to their small size and presence in very few numbers," says Bhartiya.

The discovery of these unique VSELs (in testes and ovaries) that do not succumb to oncotherapy "opens up an alternative strategy to regenerate non-functional gonads and ovaries in cancer survivors", says Bhartiya.

While VSELs survive cancer treatment, their original "habitat" (or niche) however gets destroyed by oncotherapy. To make the VSELs functional, their "niche" should be re-created by transplanting "mesenchymal cells" -- another type of taken from the bone marrow -- into the testes, says the report.

A simple and direct of "mesenchymal cells in the non-functional gonads may suffice to regenerate them," says Bhartiya. "Similarly, of "ovarian surface epithelial cells" may allow the VSELs to regenerate nonfunctional ovaries."

"This approach to fertility restoration is safe," says Bhartiya pointing out to earlier studies carried out in her laboratory in mice which had shown that this method restored the role of non-functional ovaries and resulted in the birth of fertile offsprings.

"Our group also successfully restored spermatogenesis (sperm production) in non-functional mouse testis by transplanting niche (mesenchymal) cells, into the testis," Bhartiya said.

In the light of these findings, she says the field of oncofertility may undergo a sea-change and existing strategies of cryopreservation of gametes and gonadal tissue for fertility preservation in cancer patients will have to be revised. "Pilot clinical studies (in humans) need to be undertaken."

"VSELs may be an alternative cell source for induced Pluripotent Stem (iPS) clls," Balu Manohar, of Stempeutics Research, a Bengaluru-based company told this "But it is still far away from the clinic as isolation and large scale expansion of these cells has to be standardised."

(K.S. Jayaraman is a He can be contacted at killugudi@hotmail.com)

--IANS

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(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Wed, April 17 2019. 11:54 IST
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