"Every night there are violations of the ceasefire and every day there are human casualties," Merkel said in the central Italian town of Assisi, where she received a prize for her efforts to promote peace.
The conflict in eastern Ukraine began in 2014 after mass protests ousted a pro-Russian government in Kiev, with more than 10,000 people dead so far despite repeated efforts to get successive ceasefires to stick, the last dating to the end of March.
Daughter of a Protestant pastor, Merkel was awarded the Peace Lamp of Saint Francis prize by Franciscan monks for "her work on reconciliation, promoting peaceful coexistence between peoples".
"We are following what's happening between Iran and Israel taking into consideration Germany's commitment to the security of Israel," she said. She is scheduled to meet later with 300 young people from 37 countries including some refugees from Syria's civil war.
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