Netanyahu's remarks, made in a cabinet meeting, feed into his ongoing efforts to sway world leaders to join the US in upping pressure on Israel's arch foe through sanctions.
"The time has come for the world to unite in the fight against terrorist organisations. It is doing so to a certain extent against the Islamic State group, but it is not doing so against Iran," Netanyahu said.
He accused European leaders of "appeasing" and "reconciling" with Iran.
Netanyahu had consistently called for the landmark 2015 accord to be altered or scrapped, saying it was too limited in scope and time-frame, and did nothing to stop Iran financing militant activities in the region.
European powers are seeking to save the nuclear deal and have vowed to keep providing Iran with the economic benefits it received from the accord.
"The appeasement of Iran abets the relentless assault on the values and security of the free societies, and the time has come for Western governments to join the strong and clear effort by the Trump administration against the terror regime in Tehran," Netanyahu said on Wednesday.
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