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At least 102 people were killed and nearly 200 others injured on Saturday when a Taliban suicide bomber exploded an ambulance laden with explosives near Sidarat Square in central Kabul where several government offices are located.
"At least 102 people killed, 196 others wounded.
We fear the number of people killed may go up," health and interior ministry sources told the local media.
The horrific explosion occurred at around 12.50 pm near the old building which still houses some ministry offices.
Kabul police spokesperson Basir Mujahid, confirmed to Efe that "a suicide bomber with a car laden with explosives tried to penetrate the complex (the ministry), but detonated the vehicle as he was being identified by police at the checkpoint".
The Taliban claimed the attack in a message on social network Twitter, stating that "a martyr in a car bomb reached the first checkpoint near the Interior Ministry".
Public hospital Jamhuriat, some NGO offices and busy local markets are also located in the area.
On Wednesday, the IS led an attack on Save the Children's headquarters in Jalalabad killing four NGO employees, a passerby and a security force member along with the five terrorists.
Although in the first nine months of 2017 the civilian death toll dropped by 6 per cent - its first decline since 2012 - the toll of 2,640 dead and 5,379 wounded, remains too high, according to a UN report.