The Padma Bhushan awardee, best known for films such "Neel Akasher Neechey", "Bhuvan Shome", "Ek Din Achanak", "Padatik" and "Mrigayaa", was one of the most acclaimed filmmakers of the country and an ambassador of parallel cinema.
"Sen passed away today around 10.30 am due to age-related ailments," a family member said.
The auteur, who has won multiple National Film awards, was known for his artistic depiction of social reality.
"Saddened at the passing away of Mrinal Sen. A great loss to the film industry. My condolences to his family," she tweeted.
"Mrinal Sen's passing away is a big loss not only to Cinema but to the world of Culture & India's civilisational values. Mrinal da radicalised cinematography by his people-centric humanistic narrative. Deepest condolences," he wrote.
Bengali film industry also mourned the loss of the illustrious director.
Parambrata Chatterjee tweeted, "End of an era... an epoch... legends never die... bhalo thakben (stay well)."
Prosenjit Chatterjee said, "At the end of the year receiving news like demise of the legend Mrinal Sen saddens and shocks us. Mrinal jethu gave a new perspective to Indian Cinema. It's a huge loss for all of us. May his soul rest in peace.