Protesters waved Israeli and pink flags, which have become a symbol of the protest movement, as they marched through Jerusalem toward a square near Netanyahu's official residence. Smaller demonstrations were taking place elsewhere across the country.
Protesters held signs that read, Saving the country, fighting corruption and Revolution.
The protesters criticize Netanyahu for what they say is his bungling of the coronavirus outbreak and its economic fallout.
Many of the protesters also oppose Netanyahu serving as prime minister while under indictment on three corruption charges: fraud, breach of trust and accepting bribes.
Netanyahu denies wrongdoing in a series of scandals involving billionaire associates and media moguls.
The protests have go on for months and kept a spotlight on Netanyahu at a time when the long-serving leader's popularity has plummeted because of his handling of the virus outbreak in Israel.
The country is emerging in gradual stages from a monthlong lockdown that the government imposed to tamp down infections.
Restrictions still in place have kept stores, hotels and restaurants closed while the Israeli economy continues to take a hit.
Israel appeared to have successfully weathered an initial outbreak in the spring, even as unemployment skyrocketed.
But a hasty reopening after a previous lockdown sent confirmed cases soaring and plunged the country toward new restrictions.
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