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Dengue virus infection may cause severe outcomes following Zika virus infection during pregnancy


It turns out that women who have previously been infected with may be at greater risk for increased damage to their fetuses and placentas if they should later become infected with the

The research was conducted by the Department of Microbiology at the at

Notably, this study is the first to report a possible mechanism for the enhancement of progression during pregnancy in an animal model.

Results of the study, 'increases Zika virus-induced damage during pregnancy,' were published in the February issue of Immunity, a journal published by Cell Press.

outbreaks were first found to be associated with including microcephaly, in which the baby is born with an and brain, in 2015 in Brazil, where dengue virus, a virus closely related to Zika virus, is endemic.

The research team led by Jean Lim, PhD, of in the of Biomedical Sciences at the at Mount Sinai, transferred into mice prior to with Zika virus during pregnancy.

The presence of these in the mice significantly increased placental damage, foetal growth, and foetal resorption. Zika-infected human placental tissues also showed increased replication in the presence of

Speaking about it, Dr. Lim said, "Our data demonstrate that antibodies generated from a previous can enhance the severity of during pregnancy."

"Our research may explain the high rate of and observed in the recent Zika virus outbreak in South America," he added.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Sat, February 09 2019. 14:58 IST